ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells

Targeting mitochondrial metabolism has emerged as a treatment option for cancer patients. The ABL tyrosine kinases promote metastasis, and enhanced ABL signaling is associated with a poor prognosis in lung adenocarcinoma patients. Here we show that ABL kinase allosteric inhibitors impair mitochondri...

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Detalles Bibliográficos
Autores principales: Luttman, Jillian Hattaway, Hoj, Jacob P., Lin, Kevin H., Lin, Jiaxing, Gu, Jing Jin, Rouse, Clay, Nichols, Amanda G., MacIver, Nancie J., Wood, Kris C., Pendergast, Ann Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579324/
https://www.ncbi.nlm.nih.gov/pubmed/34706244
http://dx.doi.org/10.1016/j.celrep.2021.109880

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