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Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice

Apolipoprotein ε4 (APOE)4 is a strong risk factor for the development of Alzheimer’s disease (AD) and aberrant sphingolipid levels have been implicated in AD. We tested the hypothesis that the APOE4 genotype affects brain sphingolipid levels in AD. Seven ceramides and sphingosine-1-phosphate (S1P) w...

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Detalles Bibliográficos
Autores principales:	den Hoedt, Sandra, Crivelli, Simone M., Leijten, Frank P. J., Losen, Mario, Stevens, Jo A. A., Mané-Damas, Marina, de Vries, Helga E., Walter, Jochen, Mirzaian, Mina, Sijbrands, Eric J. G., Aerts, Johannes M. F. G., Verhoeven, Adrie J. M., Martinez-Martinez, Pilar, Mulder, Monique T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579780/ https://www.ncbi.nlm.nih.gov/pubmed/34776936 http://dx.doi.org/10.3389/fnagi.2021.765252

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