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Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child

PURPOSE: To report a case of pseudotumor cerebri (PTC) in a child associated with multisystem inflammatory syndrome in children (MIS-C), associated with presumed coronavirus disease 2019. METHODS: A previously healthy 11-year-old female child presented with a 4-day history of fever, headache, vomiti...

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Autores principales: Divya, Karuppannasamy, Indumathi, Chellappan, Vikrant, Kanagaraju, Padmanaban, Sundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579781/
https://www.ncbi.nlm.nih.gov/pubmed/34765829
http://dx.doi.org/10.4103/joco.joco_241_20
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author Divya, Karuppannasamy
Indumathi, Chellappan
Vikrant, Kanagaraju
Padmanaban, Sundaram
author_facet Divya, Karuppannasamy
Indumathi, Chellappan
Vikrant, Kanagaraju
Padmanaban, Sundaram
author_sort Divya, Karuppannasamy
collection PubMed
description PURPOSE: To report a case of pseudotumor cerebri (PTC) in a child associated with multisystem inflammatory syndrome in children (MIS-C), associated with presumed coronavirus disease 2019. METHODS: A previously healthy 11-year-old female child presented with a 4-day history of fever, headache, vomiting, and loose stools. Laboratory investigations revealed neutrophilic leukocytosis, and markers of inflammation (C-reactive protein, ferritin, and interleukin-6) were significantly elevated. Pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction was negative while anti-SARS-CoV-2 antibody was highly reactive. Ophthalmic evaluation for transient visual obscurations during hospital course revealed swelling of the optic disc in both eyes. Spectral-domain optical coherence tomography and ultrasonography confirmed the ophthalmoscopic findings. There was no neurologic deficit. Magnetic resonance imaging of the brain and magnetic resonance venogram revealed no structural lesion. The opening pressure of cerebrospinal fluid (CSF) was 336 mm of water, and CSF composition was normal. RESULTS: A diagnosis of PTC associated with MIS-C was made, and the child was treated with oral acetazolamide. Edema of the optic disc regressed following therapy, and the child is under follow-up. CONCLUSIONS: PTC can occur in association with MIS-C. Clinicians need to be aware of this potential neuro-ophthalmic complication in MIS-C. Prompt diagnosis and treatment can prevent visual loss.
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spelling pubmed-85797812021-11-10 Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child Divya, Karuppannasamy Indumathi, Chellappan Vikrant, Kanagaraju Padmanaban, Sundaram J Curr Ophthalmol Case Report PURPOSE: To report a case of pseudotumor cerebri (PTC) in a child associated with multisystem inflammatory syndrome in children (MIS-C), associated with presumed coronavirus disease 2019. METHODS: A previously healthy 11-year-old female child presented with a 4-day history of fever, headache, vomiting, and loose stools. Laboratory investigations revealed neutrophilic leukocytosis, and markers of inflammation (C-reactive protein, ferritin, and interleukin-6) were significantly elevated. Pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction was negative while anti-SARS-CoV-2 antibody was highly reactive. Ophthalmic evaluation for transient visual obscurations during hospital course revealed swelling of the optic disc in both eyes. Spectral-domain optical coherence tomography and ultrasonography confirmed the ophthalmoscopic findings. There was no neurologic deficit. Magnetic resonance imaging of the brain and magnetic resonance venogram revealed no structural lesion. The opening pressure of cerebrospinal fluid (CSF) was 336 mm of water, and CSF composition was normal. RESULTS: A diagnosis of PTC associated with MIS-C was made, and the child was treated with oral acetazolamide. Edema of the optic disc regressed following therapy, and the child is under follow-up. CONCLUSIONS: PTC can occur in association with MIS-C. Clinicians need to be aware of this potential neuro-ophthalmic complication in MIS-C. Prompt diagnosis and treatment can prevent visual loss. Wolters Kluwer - Medknow 2021-10-22 /pmc/articles/PMC8579781/ /pubmed/34765829 http://dx.doi.org/10.4103/joco.joco_241_20 Text en Copyright: © 2021 Journal of Current Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Divya, Karuppannasamy
Indumathi, Chellappan
Vikrant, Kanagaraju
Padmanaban, Sundaram
Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title_full Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title_fullStr Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title_full_unstemmed Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title_short Pseudotumor Cerebri Complicating Multisystem Inflammatory Syndrome in a Child
title_sort pseudotumor cerebri complicating multisystem inflammatory syndrome in a child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579781/
https://www.ncbi.nlm.nih.gov/pubmed/34765829
http://dx.doi.org/10.4103/joco.joco_241_20
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