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Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health

BACKGROUND: Few epigenetics studies have been conducted within the Black community to examine the impact of diverse psychosocial stressors and resources for resiliency on the stress pathway (hypothalamus–pituitary–adrenal axis). METHODS: Among 1000 participants from the Black Women's Health Stu...

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Autores principales: Shields, Alexandra E, Zhang, Yuankai, Argentieri, M Austin, Warner, Erica T, Cozier, Yvette C, Liu, Chunyu, Dye, Christian K, Kent, Blake Victor, Baccarelli, Andrea A, Palmer, Julie R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579940/
https://www.ncbi.nlm.nih.gov/pubmed/34726080
http://dx.doi.org/10.2217/epi-2021-0275
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author Shields, Alexandra E
Zhang, Yuankai
Argentieri, M Austin
Warner, Erica T
Cozier, Yvette C
Liu, Chunyu
Dye, Christian K
Kent, Blake Victor
Baccarelli, Andrea A
Palmer, Julie R
author_facet Shields, Alexandra E
Zhang, Yuankai
Argentieri, M Austin
Warner, Erica T
Cozier, Yvette C
Liu, Chunyu
Dye, Christian K
Kent, Blake Victor
Baccarelli, Andrea A
Palmer, Julie R
author_sort Shields, Alexandra E
collection PubMed
description BACKGROUND: Few epigenetics studies have been conducted within the Black community to examine the impact of diverse psychosocial stressors and resources for resiliency on the stress pathway (hypothalamus–pituitary–adrenal axis). METHODS: Among 1000 participants from the Black Women's Health Study, associations between ten psychosocial stressors and DNA methylation (DNAm) of four stress-related genes (NR3C1, HSDB1, HSD11B2 and FKBP5) were tested. Whether religiosity or spirituality (R/S) significantly modified these stress-DNAm associations was also assessed. RESULTS: Associations were found for several stressors with DNAm of individual CpG loci and average DNAm levels across each gene, but no associations remained significant after false discovery rate (FDR) correction. Several R/S variables appeared to modify the relationship between two stressors and DNAm, but no identified interaction remained significant after FDR correction. CONCLUSION: There is limited evidence for a strong signal between stress and DNAm of hypothalamus–pituitary–adrenal axis genes in this general population cohort of US Black women.
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spelling pubmed-85799402021-11-10 Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health Shields, Alexandra E Zhang, Yuankai Argentieri, M Austin Warner, Erica T Cozier, Yvette C Liu, Chunyu Dye, Christian K Kent, Blake Victor Baccarelli, Andrea A Palmer, Julie R Epigenomics Research Article BACKGROUND: Few epigenetics studies have been conducted within the Black community to examine the impact of diverse psychosocial stressors and resources for resiliency on the stress pathway (hypothalamus–pituitary–adrenal axis). METHODS: Among 1000 participants from the Black Women's Health Study, associations between ten psychosocial stressors and DNA methylation (DNAm) of four stress-related genes (NR3C1, HSDB1, HSD11B2 and FKBP5) were tested. Whether religiosity or spirituality (R/S) significantly modified these stress-DNAm associations was also assessed. RESULTS: Associations were found for several stressors with DNAm of individual CpG loci and average DNAm levels across each gene, but no associations remained significant after false discovery rate (FDR) correction. Several R/S variables appeared to modify the relationship between two stressors and DNAm, but no identified interaction remained significant after FDR correction. CONCLUSION: There is limited evidence for a strong signal between stress and DNAm of hypothalamus–pituitary–adrenal axis genes in this general population cohort of US Black women. Future Medicine Ltd 2021-11-02 2021-11 /pmc/articles/PMC8579940/ /pubmed/34726080 http://dx.doi.org/10.2217/epi-2021-0275 Text en © 2021 The authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Shields, Alexandra E
Zhang, Yuankai
Argentieri, M Austin
Warner, Erica T
Cozier, Yvette C
Liu, Chunyu
Dye, Christian K
Kent, Blake Victor
Baccarelli, Andrea A
Palmer, Julie R
Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title_full Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title_fullStr Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title_full_unstemmed Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title_short Stress and spirituality in relation to HPA axis gene methylation among US Black women: results from the Black Women's Health Study and the Study on Stress, Spirituality and Health
title_sort stress and spirituality in relation to hpa axis gene methylation among us black women: results from the black women's health study and the study on stress, spirituality and health
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579940/
https://www.ncbi.nlm.nih.gov/pubmed/34726080
http://dx.doi.org/10.2217/epi-2021-0275
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