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REGEN-COV(®) antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantification
Aim: In response to the COVID-19 pandemic, Regeneron developed the anti-SARS-CoV-2 monoclonal antibody cocktail, REGEN-COV(®) (RONAPREVE(®) outside the USA). Drug concentration data was important for determination of dose, so a two-part bioanalytical strategy was implemented to ensure the therapy wa...
Autores principales: | Irvin, Susan C, Ganguly, Samit, Weiss, Rachel, Elango, Chinnasamy, Zhong, Xuefei, Mao, Yuan, Yan, Hong, Li, Ning, Sumner, Giane, Turner, Kenneth C, Davis, John D, DiCioccio, A Thomas, Andisik, Matthew D, Partridge, Michael A, Torri, Albert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Newlands Press Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579949/ https://www.ncbi.nlm.nih.gov/pubmed/34743612 http://dx.doi.org/10.4155/bio-2021-0190 |
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