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Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations
Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for ev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579951/ https://www.ncbi.nlm.nih.gov/pubmed/34596043 http://dx.doi.org/10.7554/eLife.70918 |
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author | Bakerlee, Christopher W Phillips, Angela M Nguyen Ba, Alex N Desai, Michael M |
author_facet | Bakerlee, Christopher W Phillips, Angela M Nguyen Ba, Alex N Desai, Michael M |
author_sort | Bakerlee, Christopher W |
collection | PubMed |
description | Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time. |
format | Online Article Text |
id | pubmed-8579951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85799512021-11-12 Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations Bakerlee, Christopher W Phillips, Angela M Nguyen Ba, Alex N Desai, Michael M eLife Evolutionary Biology Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of specialists or generalists, and are critical for evolution in temporally or spatially fluctuating environments. While many experiments have examined the pleiotropic effects of adaptation at a snapshot in time, very few have observed the dynamics by which these effects emerge and evolve. Here, we propagated hundreds of diploid and haploid laboratory budding yeast populations in each of three environments, and then assayed their fitness in multiple environments over 1000 generations of evolution. We find that replicate populations evolved in the same condition share common patterns of pleiotropic effects across other environments, which emerge within the first several hundred generations of evolution. However, we also find dynamic and environment-specific variability within these trends: variability in pleiotropic effects tends to increase over time, with the extent of variability depending on the evolution environment. These results suggest shifting and overlapping contributions of chance and contingency to the pleiotropic effects of adaptation, which could influence evolutionary trajectories in complex environments that fluctuate across space and time. eLife Sciences Publications, Ltd 2021-10-01 /pmc/articles/PMC8579951/ /pubmed/34596043 http://dx.doi.org/10.7554/eLife.70918 Text en © 2021, Bakerlee et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Evolutionary Biology Bakerlee, Christopher W Phillips, Angela M Nguyen Ba, Alex N Desai, Michael M Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title | Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title_full | Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title_fullStr | Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title_full_unstemmed | Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title_short | Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
title_sort | dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations |
topic | Evolutionary Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579951/ https://www.ncbi.nlm.nih.gov/pubmed/34596043 http://dx.doi.org/10.7554/eLife.70918 |
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