Cargando…

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease. Macrophages have key roles in atherosclerosis progression and, therefore, ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Wei, Schilperoort, Maaike, Cao, Yihai, Shi, Jinjun, Tabas, Ira, Tao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580169/
https://www.ncbi.nlm.nih.gov/pubmed/34759324
http://dx.doi.org/10.1038/s41569-021-00629-x
_version_ 1784596557796999168
author Chen, Wei
Schilperoort, Maaike
Cao, Yihai
Shi, Jinjun
Tabas, Ira
Tao, Wei
author_facet Chen, Wei
Schilperoort, Maaike
Cao, Yihai
Shi, Jinjun
Tabas, Ira
Tao, Wei
author_sort Chen, Wei
collection PubMed
description Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease. Macrophages have key roles in atherosclerosis progression and, therefore, macrophage-associated pathological processes are important targets for both diagnostic imaging and novel therapies for atherosclerosis. In this Review, we highlight efforts in the past two decades to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles. We review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages. Using novel molecular imaging technology, these modalities enable the identification of advanced atherosclerotic plaques and the assessment of the therapeutic efficacy of medical interventions. Additionally, we provide novel perspectives on how macrophage-targeting nanoparticles can deliver a broad range of therapeutic payloads to atherosclerotic lesions. These nanoparticles can suppress pro-atherogenic macrophage processes, leading to improved resolution of inflammation and stabilization of plaques. Finally, we propose future opportunities for novel diagnostic and therapeutic strategies and provide solutions to challenges in this area for the purpose of accelerating the clinical translation of nanomedicine for the treatment of atherosclerotic vascular disease.
format Online
Article
Text
id pubmed-8580169
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-85801692021-11-12 Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis Chen, Wei Schilperoort, Maaike Cao, Yihai Shi, Jinjun Tabas, Ira Tao, Wei Nat Rev Cardiol Review Article Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease. Macrophages have key roles in atherosclerosis progression and, therefore, macrophage-associated pathological processes are important targets for both diagnostic imaging and novel therapies for atherosclerosis. In this Review, we highlight efforts in the past two decades to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles. We review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages. Using novel molecular imaging technology, these modalities enable the identification of advanced atherosclerotic plaques and the assessment of the therapeutic efficacy of medical interventions. Additionally, we provide novel perspectives on how macrophage-targeting nanoparticles can deliver a broad range of therapeutic payloads to atherosclerotic lesions. These nanoparticles can suppress pro-atherogenic macrophage processes, leading to improved resolution of inflammation and stabilization of plaques. Finally, we propose future opportunities for novel diagnostic and therapeutic strategies and provide solutions to challenges in this area for the purpose of accelerating the clinical translation of nanomedicine for the treatment of atherosclerotic vascular disease. Nature Publishing Group UK 2021-11-10 2022 /pmc/articles/PMC8580169/ /pubmed/34759324 http://dx.doi.org/10.1038/s41569-021-00629-x Text en © Springer Nature Limited 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Chen, Wei
Schilperoort, Maaike
Cao, Yihai
Shi, Jinjun
Tabas, Ira
Tao, Wei
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title_full Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title_fullStr Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title_full_unstemmed Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title_short Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
title_sort macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580169/
https://www.ncbi.nlm.nih.gov/pubmed/34759324
http://dx.doi.org/10.1038/s41569-021-00629-x
work_keys_str_mv AT chenwei macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis
AT schilperoortmaaike macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis
AT caoyihai macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis
AT shijinjun macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis
AT tabasira macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis
AT taowei macrophagetargetednanomedicineforthediagnosisandtreatmentofatherosclerosis