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Charting host-microbe co-metabolism in skin aging and application to metagenomics data

During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay b...

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Autores principales: Alkema, Wynand, Boekhorst, Jos, Eijlander, Robyn T., Schnittger, Steve, De Gruyter, Fini, Lukovac, Sabina, Schilling, Kurt, Kortman, Guus A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580226/
https://www.ncbi.nlm.nih.gov/pubmed/34758050
http://dx.doi.org/10.1371/journal.pone.0258960
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author Alkema, Wynand
Boekhorst, Jos
Eijlander, Robyn T.
Schnittger, Steve
De Gruyter, Fini
Lukovac, Sabina
Schilling, Kurt
Kortman, Guus A. M.
author_facet Alkema, Wynand
Boekhorst, Jos
Eijlander, Robyn T.
Schnittger, Steve
De Gruyter, Fini
Lukovac, Sabina
Schilling, Kurt
Kortman, Guus A. M.
author_sort Alkema, Wynand
collection PubMed
description During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully understood. To obtain more insight into the connection between the skin microbiome and the human physiological processes involved in skin aging, we performed a systematic study on interconnected pathways of human and bacterial metabolic processes that are known to play a role in skin aging. The bacterial genes in these pathways were subsequently used to create Hidden Markov Models (HMMs), which were applied to screen for presence of defined functionalities in both genomic and metagenomic datasets of skin-associated bacteria. These models were further applied on 16S rRNA gene sequencing data from skin microbiota samples derived from female volunteers of two different age groups (25–28 years (‘young’) and 59–68 years (‘old’)). The results show that the main bacterial pathways associated with aging skin are those involved in the production of pigmentation intermediates, fatty acids and ceramides. This study furthermore provides evidence for a relation between skin aging and bacterial enzymes involved in protein glycation. Taken together, the results and insights described in this paper provide new leads for intervening with bacterial processes that are associated with aging of human skin.
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spelling pubmed-85802262021-11-11 Charting host-microbe co-metabolism in skin aging and application to metagenomics data Alkema, Wynand Boekhorst, Jos Eijlander, Robyn T. Schnittger, Steve De Gruyter, Fini Lukovac, Sabina Schilling, Kurt Kortman, Guus A. M. PLoS One Research Article During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully understood. To obtain more insight into the connection between the skin microbiome and the human physiological processes involved in skin aging, we performed a systematic study on interconnected pathways of human and bacterial metabolic processes that are known to play a role in skin aging. The bacterial genes in these pathways were subsequently used to create Hidden Markov Models (HMMs), which were applied to screen for presence of defined functionalities in both genomic and metagenomic datasets of skin-associated bacteria. These models were further applied on 16S rRNA gene sequencing data from skin microbiota samples derived from female volunteers of two different age groups (25–28 years (‘young’) and 59–68 years (‘old’)). The results show that the main bacterial pathways associated with aging skin are those involved in the production of pigmentation intermediates, fatty acids and ceramides. This study furthermore provides evidence for a relation between skin aging and bacterial enzymes involved in protein glycation. Taken together, the results and insights described in this paper provide new leads for intervening with bacterial processes that are associated with aging of human skin. Public Library of Science 2021-11-10 /pmc/articles/PMC8580226/ /pubmed/34758050 http://dx.doi.org/10.1371/journal.pone.0258960 Text en © 2021 Alkema et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alkema, Wynand
Boekhorst, Jos
Eijlander, Robyn T.
Schnittger, Steve
De Gruyter, Fini
Lukovac, Sabina
Schilling, Kurt
Kortman, Guus A. M.
Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title_full Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title_fullStr Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title_full_unstemmed Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title_short Charting host-microbe co-metabolism in skin aging and application to metagenomics data
title_sort charting host-microbe co-metabolism in skin aging and application to metagenomics data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580226/
https://www.ncbi.nlm.nih.gov/pubmed/34758050
http://dx.doi.org/10.1371/journal.pone.0258960
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