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Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears

Meniscus tears of the knee are among the most common orthopedic knee injury. Specifically, tears of the posterior root can result in abnormal meniscal extrusion leading to decreased function and progressive osteoarthritis. Despite contemporary surgical treatments of posterior meniscus root tears, th...

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Autores principales: Walczak, Brian E., Miller, Kyle, Behun, Michael A., Sienkiewicz, Lisa, Hartwig Stokes, Heather, McCabe, Ron, Baer, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580232/
https://www.ncbi.nlm.nih.gov/pubmed/34758053
http://dx.doi.org/10.1371/journal.pone.0259678
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author Walczak, Brian E.
Miller, Kyle
Behun, Michael A.
Sienkiewicz, Lisa
Hartwig Stokes, Heather
McCabe, Ron
Baer, Geoffrey S.
author_facet Walczak, Brian E.
Miller, Kyle
Behun, Michael A.
Sienkiewicz, Lisa
Hartwig Stokes, Heather
McCabe, Ron
Baer, Geoffrey S.
author_sort Walczak, Brian E.
collection PubMed
description Meniscus tears of the knee are among the most common orthopedic knee injury. Specifically, tears of the posterior root can result in abnormal meniscal extrusion leading to decreased function and progressive osteoarthritis. Despite contemporary surgical treatments of posterior meniscus root tears, there is a low rate of healing and an incidence of residual meniscus extrusion approaching 30%, illustrating an inability to recapitulate native meniscus function. Here, we characterized the differential functional behavior of the medial and lateral meniscus during axial compression load and dynamic knee motion using a cadaveric model. We hypothesized essential differences in extrusion between the medial and lateral meniscus in response to axial compression and knee range of motion. We found no differences in the amount of meniscus extrusion between the medial and lateral meniscus with a competent posterior root (0.338mm vs. 0.235mm; p-value = 0.181). However, posterior root detachment resulted in a consistently increased meniscus extrusion for the medial meniscus compared to the lateral meniscus (2.233mm vs. 0.4705mm; p-value < 0.0001). Moreover, detachment of the posterior root of the medial meniscus resulted in an increase in extrusion at all angles of knee flexion and was most pronounced (4.00mm ± 1.26mm) at 30-degrees of knee flexion. In contrast, the maximum mean extrusion of the lateral meniscus was 1.65mm ± 0.97mm, occurring in full extension. Furthermore, only the medial meniscus extruded during dynamic knee flexion after posterior root detachment. Given the differential functional behaviors between the medial and lateral meniscus, these findings suggest that posterior root repair requires reducing overall meniscus extrusion and recapitulating the native functional responses specific to each meniscus.
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spelling pubmed-85802322021-11-11 Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears Walczak, Brian E. Miller, Kyle Behun, Michael A. Sienkiewicz, Lisa Hartwig Stokes, Heather McCabe, Ron Baer, Geoffrey S. PLoS One Research Article Meniscus tears of the knee are among the most common orthopedic knee injury. Specifically, tears of the posterior root can result in abnormal meniscal extrusion leading to decreased function and progressive osteoarthritis. Despite contemporary surgical treatments of posterior meniscus root tears, there is a low rate of healing and an incidence of residual meniscus extrusion approaching 30%, illustrating an inability to recapitulate native meniscus function. Here, we characterized the differential functional behavior of the medial and lateral meniscus during axial compression load and dynamic knee motion using a cadaveric model. We hypothesized essential differences in extrusion between the medial and lateral meniscus in response to axial compression and knee range of motion. We found no differences in the amount of meniscus extrusion between the medial and lateral meniscus with a competent posterior root (0.338mm vs. 0.235mm; p-value = 0.181). However, posterior root detachment resulted in a consistently increased meniscus extrusion for the medial meniscus compared to the lateral meniscus (2.233mm vs. 0.4705mm; p-value < 0.0001). Moreover, detachment of the posterior root of the medial meniscus resulted in an increase in extrusion at all angles of knee flexion and was most pronounced (4.00mm ± 1.26mm) at 30-degrees of knee flexion. In contrast, the maximum mean extrusion of the lateral meniscus was 1.65mm ± 0.97mm, occurring in full extension. Furthermore, only the medial meniscus extruded during dynamic knee flexion after posterior root detachment. Given the differential functional behaviors between the medial and lateral meniscus, these findings suggest that posterior root repair requires reducing overall meniscus extrusion and recapitulating the native functional responses specific to each meniscus. Public Library of Science 2021-11-10 /pmc/articles/PMC8580232/ /pubmed/34758053 http://dx.doi.org/10.1371/journal.pone.0259678 Text en © 2021 Walczak et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Walczak, Brian E.
Miller, Kyle
Behun, Michael A.
Sienkiewicz, Lisa
Hartwig Stokes, Heather
McCabe, Ron
Baer, Geoffrey S.
Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title_full Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title_fullStr Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title_full_unstemmed Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title_short Quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
title_sort quantifying the differential functional behavior between the medial and lateral meniscus after posterior meniscus root tears
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580232/
https://www.ncbi.nlm.nih.gov/pubmed/34758053
http://dx.doi.org/10.1371/journal.pone.0259678
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