Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations

BACKGROUND: Two-sample Mendelian randomization (MR) allows the use of freely accessible summary association results from genome-wide association studies (GWAS) to estimate causal effects of modifiable exposures on outcomes. Some GWAS adjust for heritable covariables in an attempt to estimate direct...

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Detalles Bibliográficos
Autores principales: Hartwig, Fernando Pires, Tilling, Kate, Davey Smith, George, Lawlor, Deborah A, Borges, Maria Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580279/
https://www.ncbi.nlm.nih.gov/pubmed/33619569
http://dx.doi.org/10.1093/ije/dyaa266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580279/
https://www.ncbi.nlm.nih.gov/pubmed/33619569
http://dx.doi.org/10.1093/ije/dyaa266

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