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Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations

BACKGROUND: Two-sample Mendelian randomization (MR) allows the use of freely accessible summary association results from genome-wide association studies (GWAS) to estimate causal effects of modifiable exposures on outcomes. Some GWAS adjust for heritable covariables in an attempt to estimate direct...

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Detalles Bibliográficos
Autores principales:	Hartwig, Fernando Pires, Tilling, Kate, Davey Smith, George, Lawlor, Deborah A, Borges, Maria Carolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580279/ https://www.ncbi.nlm.nih.gov/pubmed/33619569 http://dx.doi.org/10.1093/ije/dyaa266

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