A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer’s disease (AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean age, 89 ± 9 years). A subset of these proteins was also differentially abundant in the brains of young APOE ε4 carriers...

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Detalles Bibliográficos
Autores principales: Roberts, Jackson A., Varma, Vijay R., An, Yang, Varma, Sudhir, Candia, Julián, Fantoni, Giovanna, Tiwari, Vinod, Anerillas, Carlos, Williamson, Andrew, Saito, Atsushi, Loeffler, Tina, Schilcher, Irene, Moaddel, Ruin, Khadeer, Mohammed, Lovett, Jacqueline, Tanaka, Toshiko, Pletnikova, Olga, Troncoso, Juan C., Bennett, David A., Albert, Marilyn S., Yu, Kaiwen, Niu, Mingming, Haroutunian, Vahram, Zhang, Bin, Peng, Junmin, Croteau, Deborah L., Resnick, Susan M., Gorospe, Myriam, Bohr, Vilhelm A., Ferrucci, Luigi, Thambisetty, Madhav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580310/
https://www.ncbi.nlm.nih.gov/pubmed/34757788
http://dx.doi.org/10.1126/sciadv.abi8178

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