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Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Frizzleds (FZD(1–10)) are G protein–coupled receptors containing an extracellular cysteine-rich domain (CRD) binding Wingless/Int-1 lipoglycoproteins (WNTs). Despite the role of WNT/FZD signaling in health and disease, our understanding of how WNT binding is translated into receptor activation and t...

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Detalles Bibliográficos
Autores principales:	Kowalski-Jahn, Maria, Schihada, Hannes, Turku, Ainoleena, Huber, Thomas, Sakmar, Thomas P., Schulte, Gunnar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580317/ https://www.ncbi.nlm.nih.gov/pubmed/34757789 http://dx.doi.org/10.1126/sciadv.abj7917

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