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Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer

Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic agents, recurrence and distant metastasis make the disease more...

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Autores principales: Sur, Subhayan, Ray, Ratna B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580380/
https://www.ncbi.nlm.nih.gov/pubmed/34765739
http://dx.doi.org/10.20517/2394-4722.2020.126
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author Sur, Subhayan
Ray, Ratna B.
author_facet Sur, Subhayan
Ray, Ratna B.
author_sort Sur, Subhayan
collection PubMed
description Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic agents, recurrence and distant metastasis make the disease more complicated to manage. Laboratory-based studies and epidemiological studies indicate important roles of nutraceuticals to manage different cancers. The plant bitter melon (Momordica charantia) is a good source of nutrients and bio-active phytochemicals such as triterpenoids, triterpene glycosides, phenolic acids, flavonoids, lectins, sterols and proteins. The plant is widely grown in Asia, Africa, and South America. Bitter melon has traditionally been used as a folk medicine and Ayurvedic medicine in Asian culture to treat diseases such as diabetes, since ancient times. The crude extract and some of the isolated pure compounds of bitter melon show potential anticancer effects against different cancers. In this review, we shed light on its effect on OSCC. Bitter melon extract has been found to inhibit cell proliferation and metabolism, induce cell death and enhance the immune defense system in the prevention of OSCC in vitro and in vivo. Thus, bitter melon may be used as an attractive chemopreventive agent in progression towards OSCC clinical study.
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spelling pubmed-85803802021-11-10 Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer Sur, Subhayan Ray, Ratna B. J Cancer Metastasis Treat Article Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic agents, recurrence and distant metastasis make the disease more complicated to manage. Laboratory-based studies and epidemiological studies indicate important roles of nutraceuticals to manage different cancers. The plant bitter melon (Momordica charantia) is a good source of nutrients and bio-active phytochemicals such as triterpenoids, triterpene glycosides, phenolic acids, flavonoids, lectins, sterols and proteins. The plant is widely grown in Asia, Africa, and South America. Bitter melon has traditionally been used as a folk medicine and Ayurvedic medicine in Asian culture to treat diseases such as diabetes, since ancient times. The crude extract and some of the isolated pure compounds of bitter melon show potential anticancer effects against different cancers. In this review, we shed light on its effect on OSCC. Bitter melon extract has been found to inhibit cell proliferation and metabolism, induce cell death and enhance the immune defense system in the prevention of OSCC in vitro and in vivo. Thus, bitter melon may be used as an attractive chemopreventive agent in progression towards OSCC clinical study. 2021-03-09 2021 /pmc/articles/PMC8580380/ /pubmed/34765739 http://dx.doi.org/10.20517/2394-4722.2020.126 Text en https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Sur, Subhayan
Ray, Ratna B.
Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title_full Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title_fullStr Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title_full_unstemmed Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title_short Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer
title_sort diverse roles of bitter melon (momordica charantia) in prevention of oral cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580380/
https://www.ncbi.nlm.nih.gov/pubmed/34765739
http://dx.doi.org/10.20517/2394-4722.2020.126
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