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The right time for senescence

Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cel...

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Detalles Bibliográficos
Autores principales: Paramos-de-Carvalho, Diogo, Jacinto, Antonio, Saúde, Leonor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580479/
https://www.ncbi.nlm.nih.gov/pubmed/34756162
http://dx.doi.org/10.7554/eLife.72449
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author Paramos-de-Carvalho, Diogo
Jacinto, Antonio
Saúde, Leonor
author_facet Paramos-de-Carvalho, Diogo
Jacinto, Antonio
Saúde, Leonor
author_sort Paramos-de-Carvalho, Diogo
collection PubMed
description Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.
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spelling pubmed-85804792021-11-12 The right time for senescence Paramos-de-Carvalho, Diogo Jacinto, Antonio Saúde, Leonor eLife Cell Biology Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field. eLife Sciences Publications, Ltd 2021-11-10 /pmc/articles/PMC8580479/ /pubmed/34756162 http://dx.doi.org/10.7554/eLife.72449 Text en © 2021, Paramos-de-Carvalho et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Paramos-de-Carvalho, Diogo
Jacinto, Antonio
Saúde, Leonor
The right time for senescence
title The right time for senescence
title_full The right time for senescence
title_fullStr The right time for senescence
title_full_unstemmed The right time for senescence
title_short The right time for senescence
title_sort right time for senescence
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580479/
https://www.ncbi.nlm.nih.gov/pubmed/34756162
http://dx.doi.org/10.7554/eLife.72449
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