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The right time for senescence
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580479/ https://www.ncbi.nlm.nih.gov/pubmed/34756162 http://dx.doi.org/10.7554/eLife.72449 |
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author | Paramos-de-Carvalho, Diogo Jacinto, Antonio Saúde, Leonor |
author_facet | Paramos-de-Carvalho, Diogo Jacinto, Antonio Saúde, Leonor |
author_sort | Paramos-de-Carvalho, Diogo |
collection | PubMed |
description | Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field. |
format | Online Article Text |
id | pubmed-8580479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85804792021-11-12 The right time for senescence Paramos-de-Carvalho, Diogo Jacinto, Antonio Saúde, Leonor eLife Cell Biology Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how “time” seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field. eLife Sciences Publications, Ltd 2021-11-10 /pmc/articles/PMC8580479/ /pubmed/34756162 http://dx.doi.org/10.7554/eLife.72449 Text en © 2021, Paramos-de-Carvalho et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Cell Biology Paramos-de-Carvalho, Diogo Jacinto, Antonio Saúde, Leonor The right time for senescence |
title | The right time for senescence |
title_full | The right time for senescence |
title_fullStr | The right time for senescence |
title_full_unstemmed | The right time for senescence |
title_short | The right time for senescence |
title_sort | right time for senescence |
topic | Cell Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580479/ https://www.ncbi.nlm.nih.gov/pubmed/34756162 http://dx.doi.org/10.7554/eLife.72449 |
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