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Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19
We present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of immune response during COVID-19 infection. The immune response is activated in asymptomatic infection, but i...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580567/ https://www.ncbi.nlm.nih.gov/pubmed/34774760 http://dx.doi.org/10.1016/j.bbapap.2021.140736 |
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author | Chen, Yang Zhang, Nan Zhang, Jie Guo, Jiangtao Dong, Shaobo Sun, Heqiang Gao, Shuaixin Zhou, Tingting Li, Min Liu, Xueyuan Guo, Yaxin Ye, Beiwei Zhao, Yingze Yu, Tongqi Zhan, Jianbo Jiang, Yongzhong Wong, Catherine C.L. Gao, George F. Liu, William J. |
author_facet | Chen, Yang Zhang, Nan Zhang, Jie Guo, Jiangtao Dong, Shaobo Sun, Heqiang Gao, Shuaixin Zhou, Tingting Li, Min Liu, Xueyuan Guo, Yaxin Ye, Beiwei Zhao, Yingze Yu, Tongqi Zhan, Jianbo Jiang, Yongzhong Wong, Catherine C.L. Gao, George F. Liu, William J. |
author_sort | Chen, Yang |
collection | PubMed |
description | We present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of immune response during COVID-19 infection. The immune response is activated in asymptomatic infection, but is dysregulated in mild and severe COVID-19 patients. Our data suggest that the turning point depends on the function of myeloid cells and neutrophils. In addition, immune defects persist into the recovery stage, until 12 months after diagnosis. Moreover, disorders of cholesterol metabolism span the entire progression of the disease, starting from asymptomatic infection and lasting to recovery. Our data suggest that prolonged dysregulation of the immune response and cholesterol metabolism might be the pivotal causative agent of other potential sequelae. Our study provides a comprehensive understanding of COVID-19 immunopathogenesis, which is instructive for the development of early intervention strategies to ameliorate complex disease sequelae. |
format | Online Article Text |
id | pubmed-8580567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85805672021-11-12 Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 Chen, Yang Zhang, Nan Zhang, Jie Guo, Jiangtao Dong, Shaobo Sun, Heqiang Gao, Shuaixin Zhou, Tingting Li, Min Liu, Xueyuan Guo, Yaxin Ye, Beiwei Zhao, Yingze Yu, Tongqi Zhan, Jianbo Jiang, Yongzhong Wong, Catherine C.L. Gao, George F. Liu, William J. Biochim Biophys Acta Proteins Proteom Regular Paper We present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of immune response during COVID-19 infection. The immune response is activated in asymptomatic infection, but is dysregulated in mild and severe COVID-19 patients. Our data suggest that the turning point depends on the function of myeloid cells and neutrophils. In addition, immune defects persist into the recovery stage, until 12 months after diagnosis. Moreover, disorders of cholesterol metabolism span the entire progression of the disease, starting from asymptomatic infection and lasting to recovery. Our data suggest that prolonged dysregulation of the immune response and cholesterol metabolism might be the pivotal causative agent of other potential sequelae. Our study provides a comprehensive understanding of COVID-19 immunopathogenesis, which is instructive for the development of early intervention strategies to ameliorate complex disease sequelae. Elsevier B.V. 2022-02-01 2021-11-11 /pmc/articles/PMC8580567/ /pubmed/34774760 http://dx.doi.org/10.1016/j.bbapap.2021.140736 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Regular Paper Chen, Yang Zhang, Nan Zhang, Jie Guo, Jiangtao Dong, Shaobo Sun, Heqiang Gao, Shuaixin Zhou, Tingting Li, Min Liu, Xueyuan Guo, Yaxin Ye, Beiwei Zhao, Yingze Yu, Tongqi Zhan, Jianbo Jiang, Yongzhong Wong, Catherine C.L. Gao, George F. Liu, William J. Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title | Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title_full | Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title_fullStr | Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title_full_unstemmed | Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title_short | Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19 |
title_sort | immune response pattern across the asymptomatic, symptomatic and convalescent periods of covid-19 |
topic | Regular Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580567/ https://www.ncbi.nlm.nih.gov/pubmed/34774760 http://dx.doi.org/10.1016/j.bbapap.2021.140736 |
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