Structural and functional significance of the amino acid differences Val(35)Thr, Ser(46)Ala, Asn(65)Ser, and Ala(94)Ser in 3C-like proteinases from SARS-CoV-2 and SARS-CoV

Three dimensional structures of (chymo)trypsin-like proteinase (3CL(pro)) from SARS-CoV-2 and SARS-CoV differ at 8 positions. We previously found that the Val(86)Leu, Lys(88)Arg, Phe(134)His, and Asn(180)Lys mutations in these enzymes can change the orientation of the N- and C-terminal domains of 3C...

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Detalles Bibliográficos
Autores principales: Denesyuk, Alexander I., Permyakov, Eugene A., Johnson, Mark S., Permyakov, Sergei E., Denessiouk, Konstantin, Uversky, Vladimir N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580570/
https://www.ncbi.nlm.nih.gov/pubmed/34774600
http://dx.doi.org/10.1016/j.ijbiomac.2021.11.043

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