Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis In Vivo

BACKGROUND: Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key cellular damage under oxidative stress in chondrocytes. Echinacoside (ECH) is the main extract and active substance of C...

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Detalles Bibliográficos
Autores principales: Lin, Zhen, Teng, Cheng, Ni, Libin, Zhang, Zhao, Lu, Xinlei, Lou, Junsheng, Wang, Libo, Wang, Yuxin, Chen, Wenhao, Zhang, Xiaolei, Lin, Zhongke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580641/
https://www.ncbi.nlm.nih.gov/pubmed/34777682
http://dx.doi.org/10.1155/2021/3137066

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