Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy

Steroid administration to patients with urea cycle disorders can cause hyperammonemia. We encountered a 36-year-old woman with neuromyelitis optica (NMO) complicated by ornithine transcarbamylase (OTC) deficiency. By reducing the doses of steroids and adequate infusion management, we were able to ad...

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Autores principales: Yoshida, Ryuto, Sasaki, Takuya, Sunouchi, Takashi, Ueda, Masayuki, Kitamura, Mizuki, Nakayama, Takahiro, Saito, Jun, Imafuku, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580751/
https://www.ncbi.nlm.nih.gov/pubmed/33867389
http://dx.doi.org/10.2169/internalmedicine.6885-20
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author Yoshida, Ryuto
Sasaki, Takuya
Sunouchi, Takashi
Ueda, Masayuki
Kitamura, Mizuki
Nakayama, Takahiro
Saito, Jun
Imafuku, Ichiro
author_facet Yoshida, Ryuto
Sasaki, Takuya
Sunouchi, Takashi
Ueda, Masayuki
Kitamura, Mizuki
Nakayama, Takahiro
Saito, Jun
Imafuku, Ichiro
author_sort Yoshida, Ryuto
collection PubMed
description Steroid administration to patients with urea cycle disorders can cause hyperammonemia. We encountered a 36-year-old woman with neuromyelitis optica (NMO) complicated by ornithine transcarbamylase (OTC) deficiency. By reducing the doses of steroids and adequate infusion management, we were able to administer pulse steroid therapy without any severe complications. This case indicates the safety of steroid treatment in patients with urea cycle disorders.
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spelling pubmed-85807512021-11-19 Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy Yoshida, Ryuto Sasaki, Takuya Sunouchi, Takashi Ueda, Masayuki Kitamura, Mizuki Nakayama, Takahiro Saito, Jun Imafuku, Ichiro Intern Med Case Report Steroid administration to patients with urea cycle disorders can cause hyperammonemia. We encountered a 36-year-old woman with neuromyelitis optica (NMO) complicated by ornithine transcarbamylase (OTC) deficiency. By reducing the doses of steroids and adequate infusion management, we were able to administer pulse steroid therapy without any severe complications. This case indicates the safety of steroid treatment in patients with urea cycle disorders. The Japanese Society of Internal Medicine 2021-04-19 2021-10-15 /pmc/articles/PMC8580751/ /pubmed/33867389 http://dx.doi.org/10.2169/internalmedicine.6885-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yoshida, Ryuto
Sasaki, Takuya
Sunouchi, Takashi
Ueda, Masayuki
Kitamura, Mizuki
Nakayama, Takahiro
Saito, Jun
Imafuku, Ichiro
Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title_full Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title_fullStr Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title_full_unstemmed Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title_short Neuromyelitis Optica Complicated by Ornithine Transcarbamylase Deficiency Treated Safely with Pulse Steroid Therapy
title_sort neuromyelitis optica complicated by ornithine transcarbamylase deficiency treated safely with pulse steroid therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580751/
https://www.ncbi.nlm.nih.gov/pubmed/33867389
http://dx.doi.org/10.2169/internalmedicine.6885-20
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