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First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580813/ https://www.ncbi.nlm.nih.gov/pubmed/34795903 http://dx.doi.org/10.1002/rcr2.877 |
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author | Leung, Cheuk Cheung Derek Chan, Yu Hong Ho, Man Ying Chan, Ming Chiu Chen, Chun Hoi Kwok, Chin Tong Yeung, Yiu Cheong |
author_facet | Leung, Cheuk Cheung Derek Chan, Yu Hong Ho, Man Ying Chan, Ming Chiu Chen, Chun Hoi Kwok, Chin Tong Yeung, Yiu Cheong |
author_sort | Leung, Cheuk Cheung Derek |
collection | PubMed |
description | Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible. |
format | Online Article Text |
id | pubmed-8580813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-85808132021-11-17 First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus Leung, Cheuk Cheung Derek Chan, Yu Hong Ho, Man Ying Chan, Ming Chiu Chen, Chun Hoi Kwok, Chin Tong Yeung, Yiu Cheong Respirol Case Rep Case Reports Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible. John Wiley & Sons, Ltd 2021-11-10 /pmc/articles/PMC8580813/ /pubmed/34795903 http://dx.doi.org/10.1002/rcr2.877 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Leung, Cheuk Cheung Derek Chan, Yu Hong Ho, Man Ying Chan, Ming Chiu Chen, Chun Hoi Kwok, Chin Tong Yeung, Yiu Cheong First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title_full | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title_fullStr | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title_full_unstemmed | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title_short | First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
title_sort | first reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580813/ https://www.ncbi.nlm.nih.gov/pubmed/34795903 http://dx.doi.org/10.1002/rcr2.877 |
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