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First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus

Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has...

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Autores principales: Leung, Cheuk Cheung Derek, Chan, Yu Hong, Ho, Man Ying, Chan, Ming Chiu, Chen, Chun Hoi, Kwok, Chin Tong, Yeung, Yiu Cheong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580813/
https://www.ncbi.nlm.nih.gov/pubmed/34795903
http://dx.doi.org/10.1002/rcr2.877
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author Leung, Cheuk Cheung Derek
Chan, Yu Hong
Ho, Man Ying
Chan, Ming Chiu
Chen, Chun Hoi
Kwok, Chin Tong
Yeung, Yiu Cheong
author_facet Leung, Cheuk Cheung Derek
Chan, Yu Hong
Ho, Man Ying
Chan, Ming Chiu
Chen, Chun Hoi
Kwok, Chin Tong
Yeung, Yiu Cheong
author_sort Leung, Cheuk Cheung Derek
collection PubMed
description Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible.
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spelling pubmed-85808132021-11-17 First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus Leung, Cheuk Cheung Derek Chan, Yu Hong Ho, Man Ying Chan, Ming Chiu Chen, Chun Hoi Kwok, Chin Tong Yeung, Yiu Cheong Respirol Case Rep Case Reports Pulmonary mucormycosis (PM) is a rare, life‐threatening fungal infection usually affecting immunocompromised patients. Its incidence is rising, with a recent outbreak associated with COVID‐19 co‐infection. Amphotericin B along with early surgery are considered the standard treatment. Recurrence has been reported in patients without adequate treatment and without permanent reversal of predisposing factors. We report a case of late recurrence of PM in a renal transplant recipient. In 2012, he was diagnosed with PM. Imaging at the time showed a lingular mass. He was treated with antifungal for 1 year until complete radiological resolution. Surgical intervention was considered but no further follow‐up action was taken. In 2020, he presented with fever and haemoptysis. Imaging again showed a lingular mass, which was confirmed to be PM by bronchoscopic lung biopsy. This case highlights the importance of secondary antifungal prophylaxis for PM if permanent reversal of immunosuppression is not possible. John Wiley & Sons, Ltd 2021-11-10 /pmc/articles/PMC8580813/ /pubmed/34795903 http://dx.doi.org/10.1002/rcr2.877 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Leung, Cheuk Cheung Derek
Chan, Yu Hong
Ho, Man Ying
Chan, Ming Chiu
Chen, Chun Hoi
Kwok, Chin Tong
Yeung, Yiu Cheong
First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title_full First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title_fullStr First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title_full_unstemmed First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title_short First reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
title_sort first reported case of late recurrence of pulmonary mucormycosis in a renal transplant recipient with poorly controlled diabetes mellitus
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580813/
https://www.ncbi.nlm.nih.gov/pubmed/34795903
http://dx.doi.org/10.1002/rcr2.877
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