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Emerging Knowledge of the Neurobiology of COVID-19
Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to b...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580843/ https://www.ncbi.nlm.nih.gov/pubmed/35219440 http://dx.doi.org/10.1016/j.psc.2021.11.001 |
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author | Butler, Matthew Cross, Benjamin Hafeez, Danish Lim, Mao Fong Morrin, Hamilton Rengasamy, Emma Rachel Pollak, Tom Nicholson, Timothy R. |
author_facet | Butler, Matthew Cross, Benjamin Hafeez, Danish Lim, Mao Fong Morrin, Hamilton Rengasamy, Emma Rachel Pollak, Tom Nicholson, Timothy R. |
author_sort | Butler, Matthew |
collection | PubMed |
description | Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and “long COVID,” which occurs in many patients with a milder acute COVID-19 illness. |
format | Online Article Text |
id | pubmed-8580843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85808432021-11-12 Emerging Knowledge of the Neurobiology of COVID-19 Butler, Matthew Cross, Benjamin Hafeez, Danish Lim, Mao Fong Morrin, Hamilton Rengasamy, Emma Rachel Pollak, Tom Nicholson, Timothy R. Psychiatr Clin North Am Article Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and “long COVID,” which occurs in many patients with a milder acute COVID-19 illness. Elsevier Inc. 2022-03 2021-11-11 /pmc/articles/PMC8580843/ /pubmed/35219440 http://dx.doi.org/10.1016/j.psc.2021.11.001 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Butler, Matthew Cross, Benjamin Hafeez, Danish Lim, Mao Fong Morrin, Hamilton Rengasamy, Emma Rachel Pollak, Tom Nicholson, Timothy R. Emerging Knowledge of the Neurobiology of COVID-19 |
title | Emerging Knowledge of the Neurobiology of COVID-19 |
title_full | Emerging Knowledge of the Neurobiology of COVID-19 |
title_fullStr | Emerging Knowledge of the Neurobiology of COVID-19 |
title_full_unstemmed | Emerging Knowledge of the Neurobiology of COVID-19 |
title_short | Emerging Knowledge of the Neurobiology of COVID-19 |
title_sort | emerging knowledge of the neurobiology of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580843/ https://www.ncbi.nlm.nih.gov/pubmed/35219440 http://dx.doi.org/10.1016/j.psc.2021.11.001 |
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