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Emerging Knowledge of the Neurobiology of COVID-19

Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to b...

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Autores principales: Butler, Matthew, Cross, Benjamin, Hafeez, Danish, Lim, Mao Fong, Morrin, Hamilton, Rengasamy, Emma Rachel, Pollak, Tom, Nicholson, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580843/
https://www.ncbi.nlm.nih.gov/pubmed/35219440
http://dx.doi.org/10.1016/j.psc.2021.11.001
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author Butler, Matthew
Cross, Benjamin
Hafeez, Danish
Lim, Mao Fong
Morrin, Hamilton
Rengasamy, Emma Rachel
Pollak, Tom
Nicholson, Timothy R.
author_facet Butler, Matthew
Cross, Benjamin
Hafeez, Danish
Lim, Mao Fong
Morrin, Hamilton
Rengasamy, Emma Rachel
Pollak, Tom
Nicholson, Timothy R.
author_sort Butler, Matthew
collection PubMed
description Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and “long COVID,” which occurs in many patients with a milder acute COVID-19 illness.
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spelling pubmed-85808432021-11-12 Emerging Knowledge of the Neurobiology of COVID-19 Butler, Matthew Cross, Benjamin Hafeez, Danish Lim, Mao Fong Morrin, Hamilton Rengasamy, Emma Rachel Pollak, Tom Nicholson, Timothy R. Psychiatr Clin North Am Article Many patients with COVID-19 will experience acute or longer-term neuropsychiatric complications. The neurobiological mechanisms behind these are beginning to emerge; however, the neurotropic hypothesis is not strongly supported by clinical data. The inflammatory response to SARS-CoV-2 is likely to be responsible for delirium and other common acute neuropsychiatric manifestations. Vascular abnormalities such as endotheliopathies contribute to stroke and cerebral microbleeds, with their attendant neuropsychiatric sequelae. Longer-term neuropsychiatric syndromes fall into 2 broad categories: neuropsychiatric deficits occurring after severe (hospitalized) COVID-19 and “long COVID,” which occurs in many patients with a milder acute COVID-19 illness. Elsevier Inc. 2022-03 2021-11-11 /pmc/articles/PMC8580843/ /pubmed/35219440 http://dx.doi.org/10.1016/j.psc.2021.11.001 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Butler, Matthew
Cross, Benjamin
Hafeez, Danish
Lim, Mao Fong
Morrin, Hamilton
Rengasamy, Emma Rachel
Pollak, Tom
Nicholson, Timothy R.
Emerging Knowledge of the Neurobiology of COVID-19
title Emerging Knowledge of the Neurobiology of COVID-19
title_full Emerging Knowledge of the Neurobiology of COVID-19
title_fullStr Emerging Knowledge of the Neurobiology of COVID-19
title_full_unstemmed Emerging Knowledge of the Neurobiology of COVID-19
title_short Emerging Knowledge of the Neurobiology of COVID-19
title_sort emerging knowledge of the neurobiology of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580843/
https://www.ncbi.nlm.nih.gov/pubmed/35219440
http://dx.doi.org/10.1016/j.psc.2021.11.001
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