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Cell cycle heterogeneity directs spontaneous 2C state entry and exit in mouse embryonic stem cells

Mouse embryonic stem cells (ESCs) show cell-to-cell heterogeneity. A small number of two-cell-like cells (2CLCs) marked by endogenous retrovirus activation emerge spontaneously. The 2CLCs are unstable and they are prone to transiting back to the pluripotent state without extrinsic stimulus. To under...

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Detalles Bibliográficos
Autores principales:	Zhu, Yuqing, Cheng, Chen, Chen, Lang, Zhang, Li, Pan, Hongru, Hou, Linxiao, Sun, Zhen, Zhang, Ling, Fu, Xudong, Chan, Kuan Yoow, Zhang, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580870/ https://www.ncbi.nlm.nih.gov/pubmed/34624246 http://dx.doi.org/10.1016/j.stemcr.2021.09.003

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