The WNT1(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV

The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts. Although such an influence was supported by subsequent studies, a mouse m...

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Detalles Bibliográficos
Autores principales: Vollersen, Nele, Zhao, Wenbo, Rolvien, Tim, Lange, Fabiola, Schmidt, Felix Nikolai, Sonntag, Stephan, Shmerling, Doron, von Kroge, Simon, Stockhausen, Kilian Elia, Sharaf, Ahmed, Schweizer, Michaela, Karsak, Meliha, Busse, Björn, Bockamp, Ernesto, Semler, Oliver, Amling, Michael, Oheim, Ralf, Schinke, Thorsten, Yorgan, Timur Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580994/
https://www.ncbi.nlm.nih.gov/pubmed/34759273
http://dx.doi.org/10.1038/s41413-021-00170-0

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