2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

2-Oxoglutarate (2OG) oxygenases are validated agrochemical and human drug targets. The potential for modulating their activity with 2OG derivatives has not been explored, possibly due to concerns regarding selectivity. We report proof-of-principle studies demonstrating selective enhancement or inhib...

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Detalles Bibliográficos
Autores principales: Nakashima, Yu, Brewitz, Lennart, Tumber, Anthony, Salah, Eidarus, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580996/
https://www.ncbi.nlm.nih.gov/pubmed/34759269
http://dx.doi.org/10.1038/s41467-021-26673-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580996/
https://www.ncbi.nlm.nih.gov/pubmed/34759269
http://dx.doi.org/10.1038/s41467-021-26673-2

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