PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm

PBX1 regulates the balance between self-renewal and differentiation of hematopoietic stem cells and maintains proto-oncogenic transcriptional pathways in early progenitors. Its increased expression was found in myeloproliferative neoplasm (MPN) patients bearing the JAK2(V617F) mutation. To investiga...

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Detalles Bibliográficos
Autores principales: Muggeo, Sharon, Crisafulli, Laura, Uva, Paolo, Fontana, Elena, Ubezio, Marta, Morenghi, Emanuela, Colombo, Federico Simone, Rigoni, Rosita, Peano, Clelia, Vezzoni, Paolo, Della Porta, Matteo Giovanni, Villa, Anna, Ficara, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581051/
https://www.ncbi.nlm.nih.gov/pubmed/34678207
http://dx.doi.org/10.1016/j.stemcr.2021.09.016

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