Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and the endolysosomal pathway in neurons. To dissect the astrocyte-specific impact of mutant CHMP2B expression, we generated astrocytes from...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Abinaya, Dittlau, Katarina Stoklund, Corsi, Giulia I., Haukedal, Henriette, Doncheva, Nadezhda T., Ramakrishna, Sarayu, Ambardar, Sheetal, Salcedo, Claudia, Schmidt, Sissel I., Zhang, Yu, Cirera, Susanna, Pihl, Maria, Schmid, Benjamin, Nielsen, Troels Tolstrup, Nielsen, Jørgen E., Kolko, Miriam, Kobolák, Julianna, Dinnyés, András, Hyttel, Poul, Palakodeti, Dasaradhi, Gorodkin, Jan, Muddashetty, Ravi S., Meyer, Morten, Aldana, Blanca I., Freude, Kristine K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581052/
https://www.ncbi.nlm.nih.gov/pubmed/34678206
http://dx.doi.org/10.1016/j.stemcr.2021.09.013

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