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β-Adrenergic signaling induces Notch-mediated salivary gland progenitor cell control

β-Adrenergic signaling blockade is a mainstay of hypertension management. One percent of patients taking β-blockers develop reduced salivary gland (SG) function. Here we investigate the role of SG progenitor cells in β-blocker-induced hyposalivation, using human SG organoid cultures (SGOs). Compared...

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Detalles Bibliográficos
Autores principales: Wang, X., Martinez, P. Serrano, Terpstra, J.H., Shaalan, A., Proctor, G.B., Spijkervet, F.K.L., Vissink, A., Bootsma, H., Kroese, F.G.M., Coppes, R.P., Pringle, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581054/
https://www.ncbi.nlm.nih.gov/pubmed/34678204
http://dx.doi.org/10.1016/j.stemcr.2021.09.015