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Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581056/ https://www.ncbi.nlm.nih.gov/pubmed/34653403 http://dx.doi.org/10.1016/j.stemcr.2021.09.010 |
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author | Wiesinger, Alexandra Boink, Gerard J.J. Christoffels, Vincent M. Devalla, Harsha D. |
author_facet | Wiesinger, Alexandra Boink, Gerard J.J. Christoffels, Vincent M. Devalla, Harsha D. |
author_sort | Wiesinger, Alexandra |
collection | PubMed |
description | Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research. |
format | Online Article Text |
id | pubmed-8581056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85810562021-11-18 Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells Wiesinger, Alexandra Boink, Gerard J.J. Christoffels, Vincent M. Devalla, Harsha D. Stem Cell Reports Review Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research. Elsevier 2021-10-14 /pmc/articles/PMC8581056/ /pubmed/34653403 http://dx.doi.org/10.1016/j.stemcr.2021.09.010 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wiesinger, Alexandra Boink, Gerard J.J. Christoffels, Vincent M. Devalla, Harsha D. Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title | Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title_full | Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title_fullStr | Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title_full_unstemmed | Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title_short | Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
title_sort | retinoic acid signaling in heart development: application in the differentiation of cardiovascular lineages from human pluripotent stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581056/ https://www.ncbi.nlm.nih.gov/pubmed/34653403 http://dx.doi.org/10.1016/j.stemcr.2021.09.010 |
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