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Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells

Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac...

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Detalles Bibliográficos
Autores principales: Wiesinger, Alexandra, Boink, Gerard J.J., Christoffels, Vincent M., Devalla, Harsha D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581056/
https://www.ncbi.nlm.nih.gov/pubmed/34653403
http://dx.doi.org/10.1016/j.stemcr.2021.09.010
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author Wiesinger, Alexandra
Boink, Gerard J.J.
Christoffels, Vincent M.
Devalla, Harsha D.
author_facet Wiesinger, Alexandra
Boink, Gerard J.J.
Christoffels, Vincent M.
Devalla, Harsha D.
author_sort Wiesinger, Alexandra
collection PubMed
description Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research.
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spelling pubmed-85810562021-11-18 Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells Wiesinger, Alexandra Boink, Gerard J.J. Christoffels, Vincent M. Devalla, Harsha D. Stem Cell Reports Review Retinoic acid (RA) signaling plays an important role during heart development in establishing anteroposterior polarity, formation of inflow and outflow tract progenitors, and growth of the ventricular compact wall. RA is also utilized as a key ingredient in protocols designed for generating cardiac cell types from pluripotent stem cells (PSCs). This review discusses the role of RA in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification. These insights will inform further development of desired cardiac cell types from human PSCs and their application in preclinical and clinical research. Elsevier 2021-10-14 /pmc/articles/PMC8581056/ /pubmed/34653403 http://dx.doi.org/10.1016/j.stemcr.2021.09.010 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wiesinger, Alexandra
Boink, Gerard J.J.
Christoffels, Vincent M.
Devalla, Harsha D.
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title_full Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title_fullStr Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title_full_unstemmed Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title_short Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells
title_sort retinoic acid signaling in heart development: application in the differentiation of cardiovascular lineages from human pluripotent stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581056/
https://www.ncbi.nlm.nih.gov/pubmed/34653403
http://dx.doi.org/10.1016/j.stemcr.2021.09.010
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