CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation

Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC maintenance. While hematopoietic-specific Cited2 deletion has a minor impac...

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Detalles Bibliográficos
Autores principales: Lawson, Hannah, van de Lagemaat, Louie N., Barile, Melania, Tavosanis, Andrea, Durko, Jozef, Villacreces, Arnaud, Bellani, Aarushi, Mapperley, Christopher, Georges, Elise, Martins-Costa, Catarina, Sepulveda, Catarina, Allen, Lewis, Campos, Joana, Campbell, Kirsteen J., O'Carroll, Dónal, Göttgens, Berthold, Cory, Suzanne, Rodrigues, Neil P., Guitart, Amelie V., Kranc, Kamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581166/
https://www.ncbi.nlm.nih.gov/pubmed/34715054
http://dx.doi.org/10.1016/j.stemcr.2021.10.001

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