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EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia
Schizophrenia is a complex and devastating disorder with unclear pathogenesis. Electroencephalogram (EEG) microstates have been suggested as a potential endophenotype for this disorder. However, no clear dynamic pattern of microstates has been found. This study aims to identify the dynamics of EEG m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581189/ https://www.ncbi.nlm.nih.gov/pubmed/34777062 http://dx.doi.org/10.3389/fpsyt.2021.761203 |
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author | Sun, Qiaoling Zhou, Jiansong Guo, Huijuan Gou, Ningzhi Lin, Ruoheng Huang, Ying Guo, Weilong Wang, Xiaoping |
author_facet | Sun, Qiaoling Zhou, Jiansong Guo, Huijuan Gou, Ningzhi Lin, Ruoheng Huang, Ying Guo, Weilong Wang, Xiaoping |
author_sort | Sun, Qiaoling |
collection | PubMed |
description | Schizophrenia is a complex and devastating disorder with unclear pathogenesis. Electroencephalogram (EEG) microstates have been suggested as a potential endophenotype for this disorder. However, no clear dynamic pattern of microstates has been found. This study aims to identify the dynamics of EEG microstates in schizophrenia and to test whether schizophrenia patients with altered clinical symptoms severity showed different microstates abnormalities compared with healthy controls. Resting-state EEG data in 46 individuals who met the ICD-10 diagnostic criteria for schizophrenia and 39 healthy controls was recorded. The patients with schizophrenia were divided into subgroups based on the level of their negative or positive symptoms assessed using the Positive and Negative Syndrome Scale. Microstate parameters (contribution, occurrence, and duration) of four prototypical microstate classes (A–D) were investigated. Compared with healthy controls, individuals with schizophrenia showed increased duration and contribution of microstate class C, decreased contribution and occurrence of microstate class B. Different microstate patterns were found between subgroups and healthy controls. Results in this study support the consistent observation of abnormal EEG microstates patterns in patients with schizophrenia and highlight the necessity to divide subjects into subgroups according to their clinical symptoms. |
format | Online Article Text |
id | pubmed-8581189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85811892021-11-12 EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia Sun, Qiaoling Zhou, Jiansong Guo, Huijuan Gou, Ningzhi Lin, Ruoheng Huang, Ying Guo, Weilong Wang, Xiaoping Front Psychiatry Psychiatry Schizophrenia is a complex and devastating disorder with unclear pathogenesis. Electroencephalogram (EEG) microstates have been suggested as a potential endophenotype for this disorder. However, no clear dynamic pattern of microstates has been found. This study aims to identify the dynamics of EEG microstates in schizophrenia and to test whether schizophrenia patients with altered clinical symptoms severity showed different microstates abnormalities compared with healthy controls. Resting-state EEG data in 46 individuals who met the ICD-10 diagnostic criteria for schizophrenia and 39 healthy controls was recorded. The patients with schizophrenia were divided into subgroups based on the level of their negative or positive symptoms assessed using the Positive and Negative Syndrome Scale. Microstate parameters (contribution, occurrence, and duration) of four prototypical microstate classes (A–D) were investigated. Compared with healthy controls, individuals with schizophrenia showed increased duration and contribution of microstate class C, decreased contribution and occurrence of microstate class B. Different microstate patterns were found between subgroups and healthy controls. Results in this study support the consistent observation of abnormal EEG microstates patterns in patients with schizophrenia and highlight the necessity to divide subjects into subgroups according to their clinical symptoms. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8581189/ /pubmed/34777062 http://dx.doi.org/10.3389/fpsyt.2021.761203 Text en Copyright © 2021 Sun, Zhou, Guo, Gou, Lin, Huang, Guo and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Sun, Qiaoling Zhou, Jiansong Guo, Huijuan Gou, Ningzhi Lin, Ruoheng Huang, Ying Guo, Weilong Wang, Xiaoping EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title | EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title_full | EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title_fullStr | EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title_full_unstemmed | EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title_short | EEG Microstates and Its Relationship With Clinical Symptoms in Patients With Schizophrenia |
title_sort | eeg microstates and its relationship with clinical symptoms in patients with schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581189/ https://www.ncbi.nlm.nih.gov/pubmed/34777062 http://dx.doi.org/10.3389/fpsyt.2021.761203 |
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