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Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography

Current Photoacoustic tomography (PAT) approaches are based on a single-element transducer that exhibits compromised performance in clinical imaging applications. For example, vascular, tumors are likely to have complicated shapes and optical absorptions, covering relatively wide spectra in acoustic...

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Autores principales: Luo, Xiaofei, Cai, Yiqi, Chen, Zeyu, Shan, Han, Sun, Xin, Lin, Qibo, Ma, Jianguo, Wang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581210/
https://www.ncbi.nlm.nih.gov/pubmed/34778242
http://dx.doi.org/10.3389/fbioe.2021.786376
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author Luo, Xiaofei
Cai, Yiqi
Chen, Zeyu
Shan, Han
Sun, Xin
Lin, Qibo
Ma, Jianguo
Wang, Bo
author_facet Luo, Xiaofei
Cai, Yiqi
Chen, Zeyu
Shan, Han
Sun, Xin
Lin, Qibo
Ma, Jianguo
Wang, Bo
author_sort Luo, Xiaofei
collection PubMed
description Current Photoacoustic tomography (PAT) approaches are based on a single-element transducer that exhibits compromised performance in clinical imaging applications. For example, vascular, tumors are likely to have complicated shapes and optical absorptions, covering relatively wide spectra in acoustic signals. The wide ultrasonic spectra make it difficult to set the detection bandwidth optimally in advance. In this work, we propose a stack-layer dual-element ultrasonic transducer for PAT. The central frequencies of the two piezoelectric elements are 3.06 MHz (99.3% bandwidth at –6 dB) and 11.07 MHz (85.2% bandwidth at –6 dB), respectively. This transducer bridges the sensitivity capability of ultrasound and the high contrast of optical methods in functional photoacoustic tomography. The dual-element transducer enabled multiscale analysis of the vascular network in rat brains. Using a multi-wavelength imaging scheme, the blood oxygen saturation was also detected. The preliminary results showed the great potential of broad-bandwidth functional PAT on vascular network visualization. The method can also be extended to whole-body imaging of small animals, breast cancer detection, and finger joint imaging.
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spelling pubmed-85812102021-11-12 Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography Luo, Xiaofei Cai, Yiqi Chen, Zeyu Shan, Han Sun, Xin Lin, Qibo Ma, Jianguo Wang, Bo Front Bioeng Biotechnol Bioengineering and Biotechnology Current Photoacoustic tomography (PAT) approaches are based on a single-element transducer that exhibits compromised performance in clinical imaging applications. For example, vascular, tumors are likely to have complicated shapes and optical absorptions, covering relatively wide spectra in acoustic signals. The wide ultrasonic spectra make it difficult to set the detection bandwidth optimally in advance. In this work, we propose a stack-layer dual-element ultrasonic transducer for PAT. The central frequencies of the two piezoelectric elements are 3.06 MHz (99.3% bandwidth at –6 dB) and 11.07 MHz (85.2% bandwidth at –6 dB), respectively. This transducer bridges the sensitivity capability of ultrasound and the high contrast of optical methods in functional photoacoustic tomography. The dual-element transducer enabled multiscale analysis of the vascular network in rat brains. Using a multi-wavelength imaging scheme, the blood oxygen saturation was also detected. The preliminary results showed the great potential of broad-bandwidth functional PAT on vascular network visualization. The method can also be extended to whole-body imaging of small animals, breast cancer detection, and finger joint imaging. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8581210/ /pubmed/34778242 http://dx.doi.org/10.3389/fbioe.2021.786376 Text en Copyright © 2021 Luo, Cai, Chen, Shan, Sun, Lin, Ma and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Luo, Xiaofei
Cai, Yiqi
Chen, Zeyu
Shan, Han
Sun, Xin
Lin, Qibo
Ma, Jianguo
Wang, Bo
Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title_full Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title_fullStr Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title_full_unstemmed Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title_short Stack-Layer Dual-Element Ultrasonic Transducer for Broadband Functional Photoacoustic Tomography
title_sort stack-layer dual-element ultrasonic transducer for broadband functional photoacoustic tomography
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581210/
https://www.ncbi.nlm.nih.gov/pubmed/34778242
http://dx.doi.org/10.3389/fbioe.2021.786376
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