Cargando…

Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8(High) T Cells Are Associated With the Cure of Human Visceral Leishmaniasis

Visceral leishmaniasis (VL) is a chronic and often fatal disease caused by protozoans of the genus Leishmania that affects millions of people worldwide. Patients with symptomatic VL have an impaired anti-Leishmania-specific CD4(+) T-cell response, which is reversed after clinical cure. In contrast,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Lorranny Santana, Barreto, Aline Silva, Bomfim, Lays Gisele Santos, Gomes, Marcos Couto, Ferreira, Nathalia Luisa Carlos, da Cruz, Geydson Silveira, Magalhães, Lucas Sousa, de Jesus, Amélia Ribeiro, Palatnik-de-Sousa, Clarisa B., Corrêa, Cristiane Bani, de Almeida, Roque Pacheco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581227/ https://www.ncbi.nlm.nih.gov/pubmed/34777391 http://dx.doi.org/10.3389/fimmu.2021.773983

Ejemplares similares

A Chimera Containing CD4+ and CD8+ T-Cell Epitopes of the Leishmania donovani Nucleoside Hydrolase (NH36) Optimizes Cross-Protection against Leishmania amazonesis Infection
por: Alves-Silva, Marcus Vinícius, et al.
Publicado: (2017)

A novel vaccine based on SARS-CoV-2 CD4(+) and CD8(+) T cell conserved epitopes from variants Alpha to Omicron
por: Palatnik-de-Sousa, Iam, et al.
Publicado: (2022)

Cross-Protective Immunity to Leishmania amazonensis is Mediated by CD4+ and CD8+ Epitopes of Leishmania donovani Nucleoside Hydrolase Terminal Domains
por: Nico, Dirlei, et al.
Publicado: (2014)

Vaccines for Canine Leishmaniasis
por: Palatnik-de-Sousa, Clarisa B.
Publicado: (2012)

CD8(+) T Cells as a Source of IFN-γ Production in Human Cutaneous Leishmaniasis
por: Nateghi Rostami, Mahmoud, et al.
Publicado: (2010)

Leishmania donovani Nucleoside Hydrolase (NH36) Domains Induce T-Cell Cytokine Responses in Human Visceral Leishmaniasis
por: Barbosa Santos, Micheli Luize, et al.
Publicado: (2017)

Development of an immunogen containing CD4(+)/CD8(+) T-cell epitopes for the prophylaxis of tegumentary leishmaniasis
por: de Andrade Ferraz, Isabela, et al.
Publicado: (2022)

One Health: The global challenge of epidemic and endemic leishmaniasis
por: Palatnik-de-Sousa, Clarisa B, et al.
Publicado: (2011)

The Role of CD4 and CD8 T Cells in Human Cutaneous Leishmaniasis
por: da Silva Santos, Claire, et al.
Publicado: (2014)

CD8(+) Granzyme B(+)–Mediated Tissue Injury vs. CD4(+)IFNγ(+)–Mediated Parasite Killing in Human Cutaneous Leishmaniasis
por: Santos, Claire da Silva, et al.
Publicado: (2013)

CD45RA, CD8β, and IFNγ Are Potential Immune Biomarkers of Human Cognitive Function
por: Esgalhado, André J., et al.
Publicado: (2020)

Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis
por: Nico, Dirlei, et al.
Publicado: (2015)

Increased thiol levels in antimony-resistant Leishmania infantum isolated from treatment-refractory visceral leishmaniasis in Brazil
por: Magalhães, Lucas S, et al.
Publicado: (2018)

Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8(+) and CD4(+)CD8(+) T Cells
por: De Pelsmaeker, Steffi, et al.
Publicado: (2019)

Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors
por: Nico, Dirlei, et al.
Publicado: (2012)

Host type I IFN signals are required for antitumor CD8(+) T cell responses through CD8α(+) dendritic cells
por: Fuertes, Mercedes B., et al.
Publicado: (2011)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

F1 Domain of the Leishmania (Leishmania) donovani Nucleoside Hydrolase Promotes a Th1 Response in Leishmania (Leishmania) infantum Cured Patients and in Asymptomatic Individuals Living in an Endemic Area of Leishmaniasis
por: Carrillo, Eugenia, et al.
Publicado: (2017)

CD8 is required during positive selection of CD4-/CD8+ T cells
Publicado: (1990)

TREM-1 Expression on the Surface of Neutrophils in Patients With Visceral Leishmaniasis Is Associated With Immunopathogenesis
por: Bomfim, Lays Gisele Santos, et al.
Publicado: (2022)

Adaptive Immunity against Leishmania Nucleoside Hydrolase Maps Its C-Terminal Domain as the Target of the CD4+ T Cell–Driven Protective Response
por: Nico, Dirlei, et al.
Publicado: (2010)

FoxP3(+)CD4(+), IFN-γ(+)CD4(+), and IFN-γ(+)CD8(+) cell levels in erosive and non-erosive types of oral lichen planus patients
por: Sun, Andy, et al.
Publicado: (2021)

Central and Effector Memory Human CD4(+) and CD8(+) T Cells during Cutaneous Leishmaniasis and after In Vitro Stimulation with Leishmania (Viannia) braziliensis Epitopes
por: de Oliveira, Beatriz Coutinho, et al.
Publicado: (2023)

Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo
por: Slade, Chris D., et al.
Publicado: (2020)

Magnitude and kinetics of multifunctional CD4(+) and CD8β(+) T cells in pigs infected with swine influenza A virus
por: Talker, Stephanie C, et al.
Publicado: (2015)

Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8(+) T Cells with IFN-γ-Mediated Suppressor Activities
por: Bahri, Rajia, et al.
Publicado: (2012)

In Vitro Induction of Regulatory CD4(+)CD8α(+) T Cells by TGF-β, IL-7 and IFN-γ
por: Van Kaer, Luc, et al.
Publicado: (2013)

CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8(+) T cells
por: Hansen, Aida S., et al.
Publicado: (2018)

Both CD4(+) and CD8(+) Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin from Bordetella pertussis in Infants, Children, and Adults
por: Dirix, Violette, et al.
Publicado: (2012)

Induction of broad multifunctional CD8+ and CD4+ T cells by hepatitis B virus antigen-based synthetic long peptides ex vivo
por: Jansen, Diahann T. S. L., et al.
Publicado: (2023)

Nucleoside Hydrolase NH 36: A Vital Enzyme for the Leishmania Genus in the Development of T-Cell Epitope Cross-Protective Vaccines
por: Palatnik-de-Sousa, Clarisa Beatriz
Publicado: (2019)

What Would Jenner and Pasteur Have Done About COVID-19 Coronavirus? The Urges of a Vaccinologist
por: Palatnik-de-Sousa, Clarisa B.
Publicado: (2020)

Portrait of an ISV Fellow
por: Palatnik de Sousa, Clarisa Beatriz
Publicado: (2020)

Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio
por: de Sousa, Rosa Hiolanda Abreu, et al.
Publicado: (2021)

Long terms trends in CD4(+) cell counts, CD8(+) cell counts, and the CD4(+) : CD8(+) ratio
por: Hughes, Rachael A., et al.
Publicado: (2018)

CD3, CD4, CD8, CD19 and CD16/CD56 positive cells in tuberculosis infection and disease: Peculiar features in children
por: Venturini, Elisabetta, et al.
Publicado: (2019)

Role of CD4(+)T, CD8(+)T Cells, and CD4(+)T/CD8(+)T Cell Ratio in Gastric Cancer and Its Clinical Significance
por: Han, Jingqi, et al.
Publicado: (2022)

Combined TLR and CD40 Triggering Induces Potent CD8(+) T Cell Expansion with Variable Dependence on Type I IFN
por: Ahonen, Cory L., et al.
Publicado: (2004)

Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants
por: Ortega, Sterling B., et al.
Publicado: (2015)

Phenotypic and Functional Profiles of Antigen-Specific CD4(+) and CD8(+) T Cells Associated With Infection Control in Patients With Cutaneous Leishmaniasis
por: Egui, Adriana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pgd31lea5fqt9lojcmbvn1213p