Cargando…
Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection
Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD. However, comprehensive lipid alterations related to AD pathogenesis remain unclear. Moreover, there is an ur...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581228/ https://www.ncbi.nlm.nih.gov/pubmed/34778409 http://dx.doi.org/10.3389/fcvm.2021.757022 |
_version_ | 1784596760527634432 |
---|---|
author | Huang, Huang Ye, Guozhu Lai, Song-qing Zou, Hua-xi Yuan, Bin Wu, Qi-cai Wan, Li Wang, Qun Zhou, Xue-liang Wang, Wen-jun Cao, Yuan-ping Huang, Jian-feng Chen, Shi-li Yang, Bi-cheng Liu, Ji-chun |
author_facet | Huang, Huang Ye, Guozhu Lai, Song-qing Zou, Hua-xi Yuan, Bin Wu, Qi-cai Wan, Li Wang, Qun Zhou, Xue-liang Wang, Wen-jun Cao, Yuan-ping Huang, Jian-feng Chen, Shi-li Yang, Bi-cheng Liu, Ji-chun |
author_sort | Huang, Huang |
collection | PubMed |
description | Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD. However, comprehensive lipid alterations related to AD pathogenesis remain unclear. Moreover, there is an urgent need for new or better biomarkers for improved risk assessment and surveillance of AD. Therefore, an untargeted lipidomic approach based on ultra-high-performance liquid chromatograph-mass spectrometry was employed to unveil plasma lipidomic alterations and potential biomarkers for AD patients in this study. We found that 278 of 439 identified lipid species were significantly altered in AD patients (n = 35) compared to normal controls (n = 32). Notably, most lipid species, including fatty acids, acylcarnitines, cholesteryl ester, ceramides, hexosylceramides, sphingomyelins, lysophosphatidylcholines, lysophosphatidylethanolamines, phosphatidylcholines, phosphatidylinositols, diacylglycerols, and triacylglycerols with total acyl chain carbon number ≥54 and/or total double bond number ≥4 were decreased, whereas phosphatidylethanolamines and triacylglycerols with total double bond number <4 accumulated in AD patients. Besides, the length and unsaturation of acyl chains in triacylglycerols and unsaturation of 1-acyl chain in phosphatidylethanolamines were decreased in AD patients. Moreover, lysophosphatidylcholines were the lipids with the largest alterations, at the center of correlation networks of lipid alterations, and had excellent performances in identifying AD patients. The area under the curve of 1.0 and accuracy rate of 100% could be easily obtained by lysophosphatidylcholine (20:0/0:0) or its combination with lysophosphatidylcholine (17:0/0:0) or lysophosphatidylcholine (20:1/0:0). This study provides novel and comprehensive plasma lipidomic signatures of AD patients, identifies lysophosphatidylcholines as excellent potential biomarkers, and would be beneficial to the pathogenetic study, risk assessment and timely diagnosis and treatment of AD. |
format | Online Article Text |
id | pubmed-8581228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85812282021-11-12 Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection Huang, Huang Ye, Guozhu Lai, Song-qing Zou, Hua-xi Yuan, Bin Wu, Qi-cai Wan, Li Wang, Qun Zhou, Xue-liang Wang, Wen-jun Cao, Yuan-ping Huang, Jian-feng Chen, Shi-li Yang, Bi-cheng Liu, Ji-chun Front Cardiovasc Med Cardiovascular Medicine Aortic dissection (AD) is a catastrophic cardiovascular emergency with a poor prognosis, and little preceding symptoms. Abnormal lipid metabolism is closely related to the pathogenesis of AD. However, comprehensive lipid alterations related to AD pathogenesis remain unclear. Moreover, there is an urgent need for new or better biomarkers for improved risk assessment and surveillance of AD. Therefore, an untargeted lipidomic approach based on ultra-high-performance liquid chromatograph-mass spectrometry was employed to unveil plasma lipidomic alterations and potential biomarkers for AD patients in this study. We found that 278 of 439 identified lipid species were significantly altered in AD patients (n = 35) compared to normal controls (n = 32). Notably, most lipid species, including fatty acids, acylcarnitines, cholesteryl ester, ceramides, hexosylceramides, sphingomyelins, lysophosphatidylcholines, lysophosphatidylethanolamines, phosphatidylcholines, phosphatidylinositols, diacylglycerols, and triacylglycerols with total acyl chain carbon number ≥54 and/or total double bond number ≥4 were decreased, whereas phosphatidylethanolamines and triacylglycerols with total double bond number <4 accumulated in AD patients. Besides, the length and unsaturation of acyl chains in triacylglycerols and unsaturation of 1-acyl chain in phosphatidylethanolamines were decreased in AD patients. Moreover, lysophosphatidylcholines were the lipids with the largest alterations, at the center of correlation networks of lipid alterations, and had excellent performances in identifying AD patients. The area under the curve of 1.0 and accuracy rate of 100% could be easily obtained by lysophosphatidylcholine (20:0/0:0) or its combination with lysophosphatidylcholine (17:0/0:0) or lysophosphatidylcholine (20:1/0:0). This study provides novel and comprehensive plasma lipidomic signatures of AD patients, identifies lysophosphatidylcholines as excellent potential biomarkers, and would be beneficial to the pathogenetic study, risk assessment and timely diagnosis and treatment of AD. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8581228/ /pubmed/34778409 http://dx.doi.org/10.3389/fcvm.2021.757022 Text en Copyright © 2021 Huang, Ye, Lai, Zou, Yuan, Wu, Wan, Wang, Zhou, Wang, Cao, Huang, Chen, Yang and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Huang, Huang Ye, Guozhu Lai, Song-qing Zou, Hua-xi Yuan, Bin Wu, Qi-cai Wan, Li Wang, Qun Zhou, Xue-liang Wang, Wen-jun Cao, Yuan-ping Huang, Jian-feng Chen, Shi-li Yang, Bi-cheng Liu, Ji-chun Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title | Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title_full | Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title_fullStr | Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title_full_unstemmed | Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title_short | Plasma Lipidomics Identifies Unique Lipid Signatures and Potential Biomarkers for Patients With Aortic Dissection |
title_sort | plasma lipidomics identifies unique lipid signatures and potential biomarkers for patients with aortic dissection |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581228/ https://www.ncbi.nlm.nih.gov/pubmed/34778409 http://dx.doi.org/10.3389/fcvm.2021.757022 |
work_keys_str_mv | AT huanghuang plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT yeguozhu plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT laisongqing plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT zouhuaxi plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT yuanbin plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT wuqicai plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT wanli plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT wangqun plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT zhouxueliang plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT wangwenjun plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT caoyuanping plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT huangjianfeng plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT chenshili plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT yangbicheng plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection AT liujichun plasmalipidomicsidentifiesuniquelipidsignaturesandpotentialbiomarkersforpatientswithaorticdissection |