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Mafenide derivatives inhibit neuroinflammation in Alzheimer's disease by regulating pyroptosis

The main mechanism of pyroptosis is Caspase‐1–mediated GSDMD cleavage, and GSDMD is also the executive protein of pyroptosis. Our previous study has shown that mafenide can inhibit pyroptosis by inhibiting the GSDMD‐Asp275 site to suppress cleavage. In this study, sulfonamide was used as the parent...

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Detalles Bibliográficos
Autores principales:	Han, Chenyang, Hu, Qiaohong, Yu, Anqi, Jiao, Qingcai, Yang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581306/ https://www.ncbi.nlm.nih.gov/pubmed/34632701 http://dx.doi.org/10.1111/jcmm.16984

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