NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells

In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelosuppression during maintenance therapy, particularly in Asian...

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Detalles Bibliográficos
Autores principales: Somazu, Shinpei, Tanaka, Yoichi, Tamai, Minori, Watanabe, Atsushi, Kagami, Keiko, Abe, Masako, Harama, Daisuke, Shinohara, Tamao, Akahane, Koshi, Goi, Kumiko, Sugita, Kanji, Moriyama, Takaya, Yang, Jun, Goto, Hiroaki, Minegishi, Masayoshi, Iwamoto, Shotaro, Takita, Junko, Inukai, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581340/
https://www.ncbi.nlm.nih.gov/pubmed/34636169
http://dx.doi.org/10.1111/jcmm.16981

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