CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Background: Bone metastasis is a frequent symptom of breast cancer and current targeted therapy has limited efficacy. Osteoclasts play critical roles to drive osteolysis and metastatic outgrowth of tumor cells in bone. Previously we identified CST6 as a secretory protein significantly downregulated...

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Detalles Bibliográficos
Autores principales: Li, Xiaoxun, Liang, Yajun, Lian, Cheng, Peng, Fangli, Xiao, Yansen, He, Yunfei, Ma, Chengxin, Wang, Yuan, Zhang, Peiyuan, Deng, Yuhan, Su, Yunpeng, Luo, Cheng, Kong, Xiangyin, Yang, Qingcheng, Liu, Tong, Hu, Guohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581426/
https://www.ncbi.nlm.nih.gov/pubmed/34815788
http://dx.doi.org/10.7150/thno.62187

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