Dissecting the heterogeneity and tumorigenesis of BRCA1 deficient mammary tumors via single cell RNA sequencing

Background: BRCA1 plays critical roles in mammary gland development and mammary tumorigenesis. And loss of BRCA1 induces mammary tumors in a stochastic manner. These tumors present great heterogeneity at both intertumor and intratumor levels. Methods: To comprehensively elucidate the heterogeneity o...

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Detalles Bibliográficos
Autores principales: Sun, Heng, Zeng, Jianming, Miao, Zhengqiang, Lei, Kuan Cheok, Huang, Chen, Hu, Lingling, Su, Sek Man, Chan, Un In, Miao, Kai, Zhang, Xu, Zhang, Aiping, Guo, Sen, Chen, Si, Meng, Ya, Deng, Min, Hao, Wenhui, Lei, Haipeng, Lin, Ying, Yang, Zhonglin, Tang, Dongjiang, Wong, Koon Ho, Zhang, Xiaohua Douglas, Xu, Xiaoling, Deng, Chu-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581428/
https://www.ncbi.nlm.nih.gov/pubmed/34815798
http://dx.doi.org/10.7150/thno.63995

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