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Quality of Life and a Surveillant Endocannabinoid System
The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581450/ https://www.ncbi.nlm.nih.gov/pubmed/34776851 http://dx.doi.org/10.3389/fnins.2021.747229 |
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author | de Melo Reis, Ricardo Augusto Isaac, Alinny Rosendo Freitas, Hércules Rezende de Almeida, Mariana Macedo Schuck, Patricia Fernanda Ferreira, Gustavo Costa Andrade-da-Costa, Belmira Lara da Silveira Trevenzoli, Isis Hara |
author_facet | de Melo Reis, Ricardo Augusto Isaac, Alinny Rosendo Freitas, Hércules Rezende de Almeida, Mariana Macedo Schuck, Patricia Fernanda Ferreira, Gustavo Costa Andrade-da-Costa, Belmira Lara da Silveira Trevenzoli, Isis Hara |
author_sort | de Melo Reis, Ricardo Augusto |
collection | PubMed |
description | The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets. |
format | Online Article Text |
id | pubmed-8581450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85814502021-11-12 Quality of Life and a Surveillant Endocannabinoid System de Melo Reis, Ricardo Augusto Isaac, Alinny Rosendo Freitas, Hércules Rezende de Almeida, Mariana Macedo Schuck, Patricia Fernanda Ferreira, Gustavo Costa Andrade-da-Costa, Belmira Lara da Silveira Trevenzoli, Isis Hara Front Neurosci Neuroscience The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8581450/ /pubmed/34776851 http://dx.doi.org/10.3389/fnins.2021.747229 Text en Copyright © 2021 de Melo Reis, Isaac, Freitas, de Almeida, Schuck, Ferreira, Andrade-da-Costa and Trevenzoli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience de Melo Reis, Ricardo Augusto Isaac, Alinny Rosendo Freitas, Hércules Rezende de Almeida, Mariana Macedo Schuck, Patricia Fernanda Ferreira, Gustavo Costa Andrade-da-Costa, Belmira Lara da Silveira Trevenzoli, Isis Hara Quality of Life and a Surveillant Endocannabinoid System |
title | Quality of Life and a Surveillant Endocannabinoid System |
title_full | Quality of Life and a Surveillant Endocannabinoid System |
title_fullStr | Quality of Life and a Surveillant Endocannabinoid System |
title_full_unstemmed | Quality of Life and a Surveillant Endocannabinoid System |
title_short | Quality of Life and a Surveillant Endocannabinoid System |
title_sort | quality of life and a surveillant endocannabinoid system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581450/ https://www.ncbi.nlm.nih.gov/pubmed/34776851 http://dx.doi.org/10.3389/fnins.2021.747229 |
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