Knockdown of SENP1 inhibits HIF-1α SUMOylation and suppresses oncogenic CCNE1 in Wilms tumor

Based on our initial bioinformatics finding of the upregulated expression of sentrin-specific protease 1 (SENP1) and cyclin E1 (CCNE1) in Wilms tumor, this study aimed to illustrate the molecular mechanism of SENP1 in Wilms tumor, which involved the hypoxia-inducible factor 1α (HIF-1α)/stanniocalcin...

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Detalles Bibliográficos
Autores principales: Zhu, Shibo, Hu, Jinhua, Cui, Yanhong, Liang, Shen, Gao, Xiaofeng, Zhang, Jin, Jia, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581455/
https://www.ncbi.nlm.nih.gov/pubmed/34820505
http://dx.doi.org/10.1016/j.omto.2021.07.007

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