Cargando…

Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels

Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. He...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Linlin, Zhao, Shuai, Xu, Feng, Wang, Yafeng, Zhou, Ruihui, Huang, Shiqian, Ding, Yuanyuan, Deng, Daling, Mao, Weike, Chen, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581481/
https://www.ncbi.nlm.nih.gov/pubmed/34776954
http://dx.doi.org/10.3389/fphar.2021.728300
_version_ 1784596818567364608
author Han, Linlin
Zhao, Shuai
Xu, Feng
Wang, Yafeng
Zhou, Ruihui
Huang, Shiqian
Ding, Yuanyuan
Deng, Daling
Mao, Weike
Chen, Xiangdong
author_facet Han, Linlin
Zhao, Shuai
Xu, Feng
Wang, Yafeng
Zhou, Ruihui
Huang, Shiqian
Ding, Yuanyuan
Deng, Daling
Mao, Weike
Chen, Xiangdong
author_sort Han, Linlin
collection PubMed
description Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. Here, we investigated whether TASK-3 channels contribute to sevoflurane-induced memory impairment by regulating hippocampal theta rhythms. In this study, the memory performance of mice was tested by contextual fear conditioning and inhibitory avoidance experiments. The hippocampal local field potentials (LFPs) were recorded from chronically implanted electrodes located in CA3 region. The results showed that sevoflurane concentration-dependently impaired the memory function of mice, as evidenced by the decreased time mice spent on freezing and reduced latencies for mice to enter the shock compartment. Our electrophysiological results revealed that sevoflurane also enhanced the spectral power of hippocampal LFPs (1–30 Hz), particularly in memory-related theta rhythms (4–12 Hz). These effects were mitigated by viral-mediated knockdown of TASK-3 channels in the hippocampal CA3 region. The knockdown of hippocampal TASK-3 channels significantly reduced the enhancing effect of sevoflurane on hippocampal theta rhythms and alleviated sevoflurane-induced memory impairment. Our data indicate that sevoflurane can increase hippocampal theta oscillations and impair memory function via TASK-3 channels.
format Online
Article
Text
id pubmed-8581481
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85814812021-11-12 Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels Han, Linlin Zhao, Shuai Xu, Feng Wang, Yafeng Zhou, Ruihui Huang, Shiqian Ding, Yuanyuan Deng, Daling Mao, Weike Chen, Xiangdong Front Pharmacol Pharmacology Sevoflurane can induce memory impairment during clinical anesthesia; however, the underlying mechanisms are largely unknown. TASK-3 channels are one of the potential targets of sevoflurane. Accumulating evidence supports a negative role of intracranial theta rhythms (4–12 Hz) in memory formation. Here, we investigated whether TASK-3 channels contribute to sevoflurane-induced memory impairment by regulating hippocampal theta rhythms. In this study, the memory performance of mice was tested by contextual fear conditioning and inhibitory avoidance experiments. The hippocampal local field potentials (LFPs) were recorded from chronically implanted electrodes located in CA3 region. The results showed that sevoflurane concentration-dependently impaired the memory function of mice, as evidenced by the decreased time mice spent on freezing and reduced latencies for mice to enter the shock compartment. Our electrophysiological results revealed that sevoflurane also enhanced the spectral power of hippocampal LFPs (1–30 Hz), particularly in memory-related theta rhythms (4–12 Hz). These effects were mitigated by viral-mediated knockdown of TASK-3 channels in the hippocampal CA3 region. The knockdown of hippocampal TASK-3 channels significantly reduced the enhancing effect of sevoflurane on hippocampal theta rhythms and alleviated sevoflurane-induced memory impairment. Our data indicate that sevoflurane can increase hippocampal theta oscillations and impair memory function via TASK-3 channels. Frontiers Media S.A. 2021-10-28 /pmc/articles/PMC8581481/ /pubmed/34776954 http://dx.doi.org/10.3389/fphar.2021.728300 Text en Copyright © 2021 Han, Zhao, Xu, Wang, Zhou, Huang, Ding, Deng, Mao and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Han, Linlin
Zhao, Shuai
Xu, Feng
Wang, Yafeng
Zhou, Ruihui
Huang, Shiqian
Ding, Yuanyuan
Deng, Daling
Mao, Weike
Chen, Xiangdong
Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title_full Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title_fullStr Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title_full_unstemmed Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title_short Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels
title_sort sevoflurane increases hippocampal theta oscillations and impairs memory via task-3 channels
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581481/
https://www.ncbi.nlm.nih.gov/pubmed/34776954
http://dx.doi.org/10.3389/fphar.2021.728300
work_keys_str_mv AT hanlinlin sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT zhaoshuai sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT xufeng sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT wangyafeng sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT zhouruihui sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT huangshiqian sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT dingyuanyuan sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT dengdaling sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT maoweike sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels
AT chenxiangdong sevofluraneincreaseshippocampalthetaoscillationsandimpairsmemoryviatask3channels