The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis

OBJECTIVE: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple steatosis to non-alcoholic steatohepatitis (NASH) i...

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Detalles Bibliográficos
Autores principales: Heida, Andries, Gruben, Nanda, Catrysse, Leen, Koehorst, Martijn, Koster, Mirjam, Kloosterhuis, Niels J., Gerding, Albert, Havinga, Rick, Bloks, Vincent W., Bongiovanni, Laura, Wolters, Justina C., van Dijk, Theo, van Loo, Geert, de Bruin, Alain, Kuipers, Folkert, Koonen, Debby P.Y., van de Sluis, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581577/
https://www.ncbi.nlm.nih.gov/pubmed/34626855
http://dx.doi.org/10.1016/j.molmet.2021.101349

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