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Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma
Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581592/ https://www.ncbi.nlm.nih.gov/pubmed/34804499 http://dx.doi.org/10.12688/f1000research.53643.2 |
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author | Yusuf, Muhtarum Indra, Indriyadevi Juniati, Sri Herawati Afriani Dewi, Yussy |
author_facet | Yusuf, Muhtarum Indra, Indriyadevi Juniati, Sri Herawati Afriani Dewi, Yussy |
author_sort | Yusuf, Muhtarum |
collection | PubMed |
description | Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC. |
format | Online Article Text |
id | pubmed-8581592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-85815922021-11-18 Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma Yusuf, Muhtarum Indra, Indriyadevi Juniati, Sri Herawati Afriani Dewi, Yussy F1000Res Research Article Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however the mechanism remains unclear. Recent studies have found that there is a relationship between response to treatment and the presence of cancer stem cells (CSCs). CD44+ cancer stem cells may cause cancer cells to be resistant to treatment. Therefore, this cross-sectional study aims to determine the correlation between CD44 + cancer stem cell expression and the histopathological types of NPC. Method: Samples were obtained from NPC biopsies of type I, II, III patients (based on WHO histopathology criteria), who had not received prior treatment. CD44+ expression was examined using immunohistochemistry methods by staining CD44+ monoclonal antibodies. The degree of CD44+ cell membrane expression was based on the immunoreactive score scale or the Remmele index scale. Results: Most histopathological types were WHO type III (21 patients, 50%), followed by type II (18 patients, 42.86%), and type I (3 patients, 7.14%). CD44 + expression on type I showed one patient had moderate positive and two patients had a high-positive expression. In type II, 10 were moderate positive and eight were high-positive. In type III, one patient was low-positive, 11 were moderate positive and nine patients were high-positive. Statistical analysis showed that the CD44+ expression difference between the three histopathology types were not statistically significant. Conclusion: There were no correlations between CD44 + expression and histopathological type of NPC. F1000 Research Limited 2021-11-03 /pmc/articles/PMC8581592/ /pubmed/34804499 http://dx.doi.org/10.12688/f1000research.53643.2 Text en Copyright: © 2021 Yusuf M et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yusuf, Muhtarum Indra, Indriyadevi Juniati, Sri Herawati Afriani Dewi, Yussy Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title | Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_full | Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_fullStr | Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_full_unstemmed | Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_short | Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
title_sort | correlation between cd44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581592/ https://www.ncbi.nlm.nih.gov/pubmed/34804499 http://dx.doi.org/10.12688/f1000research.53643.2 |
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