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The Effects of 5-Fluorouracil/Leucovorin Chemotherapy on Cognitive Function in Male Mice

5-Fluorouracil (5-Fu) and leucovorin (LV) are often given in combination to treat colorectal cancer. 5-Fu/LV prevents cell proliferation by inhibiting thymidylate synthase, which catalyzes the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate. While 5-Fu has been shown to caus...

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Detalles Bibliográficos
Autores principales:	Groves, Thomas, Corley, Christa, Byrum, Stephanie D., Allen, Antiño R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581634/ https://www.ncbi.nlm.nih.gov/pubmed/34778377 http://dx.doi.org/10.3389/fmolb.2021.762116

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