Dravet Variant SCN1A(A1783V) Impairs Interneuron Firing Predominantly by Altered Channel Activation

Dravet syndrome (DS) is a developmental epileptic encephalopathy mainly caused by functional Na(V)1.1 haploinsufficiency in inhibitory interneurons. Recently, a new conditional mouse model expressing the recurrent human p.(Ala1783Val) missense variant has become available. In this study, we provided...

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Detalles Bibliográficos
Autores principales: Layer, Nikolas, Sonnenberg, Lukas, Pardo González, Emilio, Benda, Jan, Hedrich, Ulrike B. S., Lerche, Holger, Koch, Henner, Wuttke, Thomas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581729/
https://www.ncbi.nlm.nih.gov/pubmed/34776868
http://dx.doi.org/10.3389/fncel.2021.754530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581729/
https://www.ncbi.nlm.nih.gov/pubmed/34776868
http://dx.doi.org/10.3389/fncel.2021.754530

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