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Scalable Biosynthetic Production of Knotted Peptides Enables ADME and Thermodynamic Folding Studies

[Image: see text] Knotted peptides present a wealth of structurally diverse, biologically active molecules, with the inhibitor cystine knot/knottin class among the most ecologically common ones. Many of these natural products interact with extracellular targets such as voltage-gated ion channels wit...

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Detalles Bibliográficos
Autores principales:	Schwalen, Christopher J., Babu, Charles, Phulera, Swastik, Hao, Qin, Wall, Daniel, Nettleton, David O., Pathak, Tejas P., Siuti, Piro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582066/ https://www.ncbi.nlm.nih.gov/pubmed/34778627 http://dx.doi.org/10.1021/acsomega.1c03707

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