Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)

[Image: see text] Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance l...

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Detalles Bibliográficos
Autores principales: Kilbile, Jaydeo T., Tamboli, Yasinalli, Rafeeq, Mohammad, Yadav, Ram Prasad, Rane, Vipul P., Bhamare, Vijay S., Merwade, Arvind Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582070/
https://www.ncbi.nlm.nih.gov/pubmed/34778670
http://dx.doi.org/10.1021/acsomega.1c04639
Descripción
Sumario:[Image: see text] Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail.

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