Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)

[Image: see text] Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance l...

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Autores principales: Kilbile, Jaydeo T., Tamboli, Yasinalli, Rafeeq, Mohammad, Yadav, Ram Prasad, Rane, Vipul P., Bhamare, Vijay S., Merwade, Arvind Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582070/
https://www.ncbi.nlm.nih.gov/pubmed/34778670
http://dx.doi.org/10.1021/acsomega.1c04639
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author Kilbile, Jaydeo T.
Tamboli, Yasinalli
Rafeeq, Mohammad
Yadav, Ram Prasad
Rane, Vipul P.
Bhamare, Vijay S.
Merwade, Arvind Y.
author_facet Kilbile, Jaydeo T.
Tamboli, Yasinalli
Rafeeq, Mohammad
Yadav, Ram Prasad
Rane, Vipul P.
Bhamare, Vijay S.
Merwade, Arvind Y.
author_sort Kilbile, Jaydeo T.
collection PubMed
description [Image: see text] Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail.
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spelling pubmed-85820702021-11-12 Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771) Kilbile, Jaydeo T. Tamboli, Yasinalli Rafeeq, Mohammad Yadav, Ram Prasad Rane, Vipul P. Bhamare, Vijay S. Merwade, Arvind Y. ACS Omega [Image: see text] Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail. American Chemical Society 2021-10-27 /pmc/articles/PMC8582070/ /pubmed/34778670 http://dx.doi.org/10.1021/acsomega.1c04639 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Kilbile, Jaydeo T.
Tamboli, Yasinalli
Rafeeq, Mohammad
Yadav, Ram Prasad
Rane, Vipul P.
Bhamare, Vijay S.
Merwade, Arvind Y.
Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title_full Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title_fullStr Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title_full_unstemmed Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title_short Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
title_sort efficient synthesis of potential impurities in levonadifloxacin (wck 771)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582070/
https://www.ncbi.nlm.nih.gov/pubmed/34778670
http://dx.doi.org/10.1021/acsomega.1c04639
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