PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8(+) T cells at the expense of central memory

Patients with activated phosphatidylinositol 3-kinase delta (PI3Kδ) syndrome (APDS) present with sinopulmonary infections, lymphadenopathy, and cytomegalvirus (CMV) and/or Epstein-Barr virus (EBV) viremia, yet why patients fail to clear certain chronic viral infections remains incompletely understoo...

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Detalles Bibliográficos
Autores principales: Cannons, Jennifer L., Villarino, Alejandro V., Kapnick, Senta M., Preite, Silvia, Shih, Han-Yu, Gomez-Rodriguez, Julio, Kaul, Zenia, Shibata, Hirofumi, Reilley, Julie M., Huang, Bonnie, Handon, Robin, McBain, Ian T., Gossa, Selamawit, Wu, Tuoqi, Su, Helen C., McGavern, Dorian B., O’Shea, John J., McGuire, Peter J., Uzel, Gulbu, Schwartzberg, Pamela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582080/
https://www.ncbi.nlm.nih.gov/pubmed/34644563
http://dx.doi.org/10.1016/j.celrep.2021.109804

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