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Nosocomial infections amongst critically ill COVID-19 patients in Australia

PURPOSE: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). METHODS: The effe...

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Autores principales: Ramanan, Mahesh, Burrell, Aidan, Paul, Eldho, Trapani, Tony, Broadley, Tessa, McGloughlin, Steve, French, Craig, Udy, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582097/
https://www.ncbi.nlm.nih.gov/pubmed/35262030
http://dx.doi.org/10.1016/j.jcvp.2021.100054
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author Ramanan, Mahesh
Burrell, Aidan
Paul, Eldho
Trapani, Tony
Broadley, Tessa
McGloughlin, Steve
French, Craig
Udy, Andrew
author_facet Ramanan, Mahesh
Burrell, Aidan
Paul, Eldho
Trapani, Tony
Broadley, Tessa
McGloughlin, Steve
French, Craig
Udy, Andrew
author_sort Ramanan, Mahesh
collection PubMed
description PURPOSE: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). METHODS: The effect of nosocomial infections on hospital mortality was evaluated using hierarchical logistic regression models to adjust for illness severity and mechanical ventilation. RESULTS: There were 490 patients admitted to 55 ICUs during the study period. Adjusted odds ratio (OR) for hospital mortality was 1.61 (95% confidence interval (CI) 0.61–4.27, p = 0.3) when considering BSI, and 1.76 (95% CI 0.73–4.21, p = 0.2) for HAP. The average adjusted ICU LOS was significantly longer for patients with BSI (geometric mean 9.0 days vs 6.3 days, p = 0.04) and HAP (geometric mean 13.9 days vs 6.0 days p<0.001). CONCLUSION: Nosocomial infection rates amongst patients with COVID-19 were low and their development was associated with a significantly longer ICU LOS.
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spelling pubmed-85820972021-11-12 Nosocomial infections amongst critically ill COVID-19 patients in Australia Ramanan, Mahesh Burrell, Aidan Paul, Eldho Trapani, Tony Broadley, Tessa McGloughlin, Steve French, Craig Udy, Andrew Journal of Clinical Virology plus Article PURPOSE: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). METHODS: The effect of nosocomial infections on hospital mortality was evaluated using hierarchical logistic regression models to adjust for illness severity and mechanical ventilation. RESULTS: There were 490 patients admitted to 55 ICUs during the study period. Adjusted odds ratio (OR) for hospital mortality was 1.61 (95% confidence interval (CI) 0.61–4.27, p = 0.3) when considering BSI, and 1.76 (95% CI 0.73–4.21, p = 0.2) for HAP. The average adjusted ICU LOS was significantly longer for patients with BSI (geometric mean 9.0 days vs 6.3 days, p = 0.04) and HAP (geometric mean 13.9 days vs 6.0 days p<0.001). CONCLUSION: Nosocomial infection rates amongst patients with COVID-19 were low and their development was associated with a significantly longer ICU LOS. The Author(s). Published by Elsevier Ltd. 2021-12 2021-11-11 /pmc/articles/PMC8582097/ /pubmed/35262030 http://dx.doi.org/10.1016/j.jcvp.2021.100054 Text en © 2021 The Author(s). Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ramanan, Mahesh
Burrell, Aidan
Paul, Eldho
Trapani, Tony
Broadley, Tessa
McGloughlin, Steve
French, Craig
Udy, Andrew
Nosocomial infections amongst critically ill COVID-19 patients in Australia
title Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_full Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_fullStr Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_full_unstemmed Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_short Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_sort nosocomial infections amongst critically ill covid-19 patients in australia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582097/
https://www.ncbi.nlm.nih.gov/pubmed/35262030
http://dx.doi.org/10.1016/j.jcvp.2021.100054
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