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Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs

BACKGROUND: Radiotherapy is routinely used to combat glioblastoma (GBM). However, the treatment efficacy is often limited by the radioresistance of GBM cells. METHODS: Two GBM lines MO59K and MO59J, differing in intrinsic radiosensitivity and mutational status of DNA-PK and ATM, were analyzed regard...

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Detalles Bibliográficos
Autores principales:	Djuzenova, Cholpon S., Fischer, Thomas, Katzer, Astrid, Sisario, Dmitri, Korsa, Tessa, Steussloff, Gudrun, Sukhorukov, Vladimir L., Flentje, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582108/ https://www.ncbi.nlm.nih.gov/pubmed/34763650 http://dx.doi.org/10.1186/s12885-021-08930-1

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